Names & Taxonomy
- Uniprot ID:
- P55011
- Entry Name:
- S12A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1)
- Gene Names:
- SLC12A2 NKCC1
- Gene Names Primary:
- SLC12A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1212
- Sequence:
- MEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKSDLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
- Enzyme Regulation:
- ENZYME REGULATION: Activated by WNK3.
- Cross Reference Drug Bank:
- DB00887 DB00761 DB01325
- Gene Ontology Go:
- apical plasma membrane
extracellular exosome
extracellular vesicle
integral component of plasma membrane
membrane
plasma membrane
ammonium transmembrane transporter activity
sodium:potassium:chloride symporter activity
ammonium transmembrane transport
ammonium transport
chloride transmembrane transport
ion transport
potassium ion transport
sodium ion transport
transepithelial ammonium transport
transepithelial chloride transport
transmembrane transport
transport - Gene Ontology Biological Process:
- ammonium transmembrane transport
ammonium transport
chloride transmembrane transport
ion transport
potassium ion transport
sodium ion transport
transepithelial ammonium transport
transepithelial chloride transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- ammonium transmembrane transporter activity
sodium:potassium:chloride symporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
extracellular exosome
extracellular vesicle
integral component of plasma membrane
membrane
plasma membrane - Keywords:
- Acetylation
Alternative splicing
Complete proteome
Ion transport
Membrane
Phosphoprotein
Potassium
Potassium transport
Reference proteome
Sodium
Sodium transport
Symport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- O95747