Names & Taxonomy
- Uniprot ID:
- P54819
- Entry Name:
- KAD2_HUMAN
- Status:
- reviewed
- Protein Names:
- Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]
- Gene Names:
- AK2 ADK2
- Gene Names Primary:
- AK2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 239
- Sequence:
- MAPSVPAAEPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPLCKNGFLLDGFPRTVRQAEMLDDLMEKRKEKLDSVIEFSIPDSLLIRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNEKALKIRLQAYHTQTTPLIEYYRKRGIHSAIDASQTPDVVFASILAAFSKATCKDLVMFI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion intermembrane space
Function
- Function:
- Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
- Catalytic Activity:
- ATP + AMP = 2 ADP.
- Cross Reference Drug Bank:
- DB00718 DB00300
- Gene Ontology Go:
- cytosol
extracellular exosome
mitochondrial inner membrane
mitochondrial intermembrane space
sperm mitochondrial sheath
adenylate kinase activity
ATP binding
ADP biosynthetic process
AMP metabolic process
brain development
dATP metabolic process
liver development
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
oxidative phosphorylation
response to thyroid hormone
small molecule metabolic process - Gene Ontology Biological Process:
- ADP biosynthetic process
AMP metabolic process
brain development
dATP metabolic process
liver development
nucleobase-containing small molecule interconversion
nucleobase-containing small molecule metabolic process
oxidative phosphorylation
response to thyroid hormone
small molecule metabolic process - Gene Ontology Molecular Function:
- adenylate kinase activity
ATP binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
mitochondrial inner membrane
mitochondrial intermembrane space
sperm mitochondrial sheath - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Kinase
Mitochondrion
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase