Names & Taxonomy

Uniprot ID:
P54802
Entry Name:
ANAG_HUMAN
Status:
reviewed
Protein Names:
Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form]
Gene Names:
NAGLU UFHSD1
Gene Names Primary:
NAGLU
Organism:
Homo sapiens (Human)

Structure

Length:
743
Sequence:
MEAVAVAAAVGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTYSLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTDHIYGADTFNEMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQFWGPAQIRAVLGAVPRGRLLVLDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARLFPNSTMVGTGMAPEGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSHPDAGAAWRLLLRSVYNCSGEACRGHNRSPLVRRPSLQMNTSIWYNRSDVFEAWRLLLTSAPSLATSPAFRYDLLDLTRQAVQELVSLYYEEARSAYLSKELASLLRAGGVLAYELLPALDEVLASDSRFLLGSWLEQARAAAVSEAEADFYEQNSRYQLTLWGPEGNILDYANKQLAGLVANYYTPRWRLFLEALVDSVAQGIPFQQHQFDKNVFQLEQAFVLSKQRYPSQPRGDTVDLAKKIFLKYYPRWVAGSW
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Lysosome.

Function

Function:
Involved in the degradation of heparan sulfate.
Catalytic Activity:
Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.
Cross Reference Drug Bank:
DB00141
Gene Ontology Go:
extracellular exosome
lysosomal lumen
lysosome
alpha-N-acetylglucosaminidase activity
carbohydrate metabolic process
cerebellar Purkinje cell layer development
glycosaminoglycan catabolic process
glycosaminoglycan metabolic process
inner ear receptor cell development
locomotor rhythm
lysosome organization
middle ear morphogenesis
nervous system development
retinal rod cell development
small molecule metabolic process
Gene Ontology Biological Process:
carbohydrate metabolic process
cerebellar Purkinje cell layer development
glycosaminoglycan catabolic process
glycosaminoglycan metabolic process
inner ear receptor cell development
locomotor rhythm
lysosome organization
middle ear morphogenesis
nervous system development
retinal rod cell development
small molecule metabolic process
Gene Ontology Molecular Function:
alpha-N-acetylglucosaminidase activity
Gene Ontology Cellular Component:
extracellular exosome
lysosomal lumen
lysosome
Keywords:
3D-structure
Charcot-Marie-Tooth disease
Complete proteome
Direct protein sequencing
Disease mutation
Glycoprotein
Glycosidase
Hydrolase
Lysosome
Mucopolysaccharidosis
Neurodegeneration
Neuropathy
Polymorphism
Reference proteome
Signal

Publication

PubMed ID:
8650226 8776591 8703123 16625196 15489334 19159218 25818867 9443875 9443878 9832037 9950362 10094189 11068184 11153910 11286389 11793481 12202988 11836372 14984474 15933803 16151907