Names & Taxonomy
- Uniprot ID:
- P54802
- Entry Name:
- ANAG_HUMAN
- Status:
- reviewed
- Protein Names:
- Alpha-N-acetylglucosaminidase (EC 3.2.1.50) (N-acetyl-alpha-glucosaminidase) (NAG) [Cleaved into: Alpha-N-acetylglucosaminidase 82 kDa form; Alpha-N-acetylglucosaminidase 77 kDa form]
- Gene Names:
- NAGLU UFHSD1
- Gene Names Primary:
- NAGLU
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 743
- Sequence:
- MEAVAVAAAVGVLLLAGAGGAAGDEAREAAAVRALVARLLGPGPAADFSVSVERALAAKPGLDTYSLGGGGAARVRVRGSTGVAAAAGLHRYLRDFCGCHVAWSGSQLRLPRPLPAVPGELTEATPNRYRYYQNVCTQSYSFVWWDWARWEREIDWMALNGINLALAWSGQEAIWQRVYLALGLTQAEINEFFTGPAFLAWGRMGNLHTWDGPLPPSWHIKQLYLQHRVLDQMRSFGMTPVLPAFAGHVPEAVTRVFPQVNVTKMGSWGHFNCSYSCSFLLAPEDPIFPIIGSLFLRELIKEFGTDHIYGADTFNEMQPPSSEPSYLAAATTAVYEAMTAVDTEAVWLLQGWLFQHQPQFWGPAQIRAVLGAVPRGRLLVLDLFAESQPVYTRTASFQGQPFIWCMLHNFGGNHGLFGALEAVNGGPEAARLFPNSTMVGTGMAPEGISQNEVVYSLMAELGWRKDPVPDLAAWVTSFAARRYGVSHPDAGAAWRLLLRSVYNCSGEACRGHNRSPLVRRPSLQMNTSIWYNRSDVFEAWRLLLTSAPSLATSPAFRYDLLDLTRQAVQELVSLYYEEARSAYLSKELASLLRAGGVLAYELLPALDEVLASDSRFLLGSWLEQARAAAVSEAEADFYEQNSRYQLTLWGPEGNILDYANKQLAGLVANYYTPRWRLFLEALVDSVAQGIPFQQHQFDKNVFQLEQAFVLSKQRYPSQPRGDTVDLAKKIFLKYYPRWVAGSW
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Function:
- Involved in the degradation of heparan sulfate.
- Catalytic Activity:
- Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.
- Cross Reference Drug Bank:
- DB00141
- Gene Ontology Go:
- extracellular exosome
lysosomal lumen
lysosome
alpha-N-acetylglucosaminidase activity
carbohydrate metabolic process
cerebellar Purkinje cell layer development
glycosaminoglycan catabolic process
glycosaminoglycan metabolic process
inner ear receptor cell development
locomotor rhythm
lysosome organization
middle ear morphogenesis
nervous system development
retinal rod cell development
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
cerebellar Purkinje cell layer development
glycosaminoglycan catabolic process
glycosaminoglycan metabolic process
inner ear receptor cell development
locomotor rhythm
lysosome organization
middle ear morphogenesis
nervous system development
retinal rod cell development
small molecule metabolic process - Gene Ontology Molecular Function:
- alpha-N-acetylglucosaminidase activity
- Gene Ontology Cellular Component:
- extracellular exosome
lysosomal lumen
lysosome - Keywords:
- 3D-structure
Charcot-Marie-Tooth disease
Complete proteome
Direct protein sequencing
Disease mutation
Glycoprotein
Glycosidase
Hydrolase
Lysosome
Mucopolysaccharidosis
Neurodegeneration
Neuropathy
Polymorphism
Reference proteome
Signal