Names & Taxonomy
- Uniprot ID:
- P54762
- Entry Name:
- EPHB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
- Gene Names:
- EPHB1 ELK EPHT2 HEK6 NET
- Gene Names Primary:
- EPHB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 984
- Sequence:
- MALDYLLLLLLASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQVCNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPAEASPICTCRTGYYRADFDPPEVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGITLAGHQKKILNSIHSMRVQISQSPTAMA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Active Site:
- ACT_SITE 744 744 Proton acceptor.
- Gene Ontology Go:
- axon
cytosol
dendrite
early endosome membrane
extracellular exosome
extracellular region
filopodium tip
integral component of plasma membrane
membrane raft
plasma membrane
ATP binding
axon guidance receptor activity
transmembrane-ephrin receptor activity
angiogenesis
axon guidance
camera-type eye morphogenesis
cell chemotaxis
cell-substrate adhesion
central nervous system projection neuron axonogenesis
dendritic spine development
dendritic spine morphogenesis
detection of temperature stimulus involved in sensory perception of pain
ephrin receptor signaling pathway
establishment of cell polarity
immunological synapse formation
neural precursor cell proliferation
neurogenesis
optic nerve morphogenesis
positive regulation of synapse assembly
protein autophosphorylation
regulation of ERK1 and ERK2 cascade
regulation of JNK cascade
regulation of neuron death
retinal ganglion cell axon guidance - Gene Ontology Biological Process:
- angiogenesis
axon guidance
camera-type eye morphogenesis
cell chemotaxis
cell-substrate adhesion
central nervous system projection neuron axonogenesis
dendritic spine development
dendritic spine morphogenesis
detection of temperature stimulus involved in sensory perception of pain
ephrin receptor signaling pathway
establishment of cell polarity
immunological synapse formation
neural precursor cell proliferation
neurogenesis
optic nerve morphogenesis
positive regulation of synapse assembly
protein autophosphorylation
regulation of ERK1 and ERK2 cascade
regulation of JNK cascade
regulation of neuron death
retinal ganglion cell axon guidance - Gene Ontology Molecular Function:
- ATP binding
axon guidance receptor activity
transmembrane-ephrin receptor activity - Gene Ontology Cellular Component:
- axon
cytosol
dendrite
early endosome membrane
extracellular exosome
extracellular region
filopodium tip
integral component of plasma membrane
membrane raft
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Endosome
Glycoprotein
Kinase
Membrane
Neurogenesis
Nucleotide-binding
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase
Ubl conjugation - Interacts With:
- Q13322; P62993; Q14451