Names & Taxonomy
- Uniprot ID:
- P54750
- Entry Name:
- PDE1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1)
- Gene Names:
- PDE1A
- Gene Names Primary:
- PDE1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 535
- Sequence:
- MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ
- Proteomes:
- UP000005640
Function
- Function:
- Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP.
- Catalytic Activity:
- Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Enzyme Regulation:
- ENZYME REGULATION: Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).
- Active Site:
- ACT_SITE 219 219 Proton donor.
- Cross Reference Drug Bank:
- DB01244 DB00201 DB01023 DB00622
- Gene Ontology Go:
- cytosol
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
metal ion binding
activation of phospholipase C activity
blood coagulation
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
neurotrophin TRK receptor signaling pathway
signal transduction - Gene Ontology Biological Process:
- activation of phospholipase C activity
blood coagulation
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
innate immune response
neurotrophin TRK receptor signaling pathway
signal transduction - Gene Ontology Molecular Function:
- calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Alternative splicing
Calmodulin-binding
Complete proteome
Hydrolase
Metal-binding
Reference proteome
cAMP
cGMP