Names & Taxonomy

Uniprot ID:
P54710
Entry Name:
ATNG_HUMAN
Status:
reviewed
Protein Names:
Sodium/potassium-transporting ATPase subunit gamma (Na(+)/K(+) ATPase subunit gamma) (FXYD domain-containing ion transport regulator 2) (Sodium pump gamma chain)
Gene Names:
FXYD2 ATP1C ATP1G1
Gene Names Primary:
FXYD2
Organism:
Homo sapiens (Human)

Structure

Length:
66
Sequence:
MTGLSMDGGGSPKGDVDPFYYDYETVRNGGLIFAGLAFIVGLLILLSRRFRCGGNKKRRQINEDEP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Cross Reference Drug Bank:
DB00606
Gene Ontology Go:
basolateral plasma membrane
extracellular exosome
intracellular membrane-bounded organelle
plasma membrane
sodium:potassium-exchanging ATPase complex
ion channel activity
sodium channel regulator activity
sodium:potassium-exchanging ATPase activity
transporter activity
ATP hydrolysis coupled transmembrane transport
cardiac conduction
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
potassium ion import across plasma membrane
regulation of cardiac conduction
regulation of cell growth
regulation of cell proliferation
regulation of sodium ion transmembrane transporter activity
sodium ion export from cell
transmembrane transport
transport
Gene Ontology Biological Process:
ATP hydrolysis coupled transmembrane transport
cardiac conduction
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
potassium ion import across plasma membrane
regulation of cardiac conduction
regulation of cell growth
regulation of cell proliferation
regulation of sodium ion transmembrane transporter activity
sodium ion export from cell
transmembrane transport
transport
Gene Ontology Molecular Function:
ion channel activity
sodium:potassium-exchanging ATPase activity
sodium channel regulator activity
transporter activity
Gene Ontology Cellular Component:
basolateral plasma membrane
extracellular exosome
intracellular membrane-bounded organelle
plasma membrane
sodium:potassium-exchanging ATPase complex
Keywords:
3D-structure
Alternative splicing
Complete proteome
Disease mutation
Ion transport
Membrane
Potassium
Potassium transport
Primary hypomagnesemia
Reference proteome
Sodium
Sodium transport
Sodium/potassium transport
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
9048881 11112438 11062458 15489334