Names & Taxonomy
- Uniprot ID:
- P54707
- Entry Name:
- AT12A_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium-transporting ATPase alpha chain 2 (EC 3.6.3.10) (Non-gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)
- Gene Names:
- ATP12A ATP1AL1
- Gene Names Primary:
- ATP12A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1039
- Sequence:
- MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSEDHSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILGDVMEIRKRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYVNDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIIIGLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.
- Catalytic Activity:
- ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).
- Active Site:
- ACT_SITE 391 391 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
hydrogen:potassium-exchanging ATPase complex
intracellular membrane-bounded organelle
plasma membrane
ATP binding
hydrogen:potassium-exchanging ATPase activity
metal ion binding
sodium:potassium-exchanging ATPase activity
ATP hydrolysis coupled proton transport
cellular potassium ion homeostasis
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
potassium ion import
regulation of pH
response to metal ion
response to organic cyclic compound
sodium ion export from cell
transmembrane transport - Gene Ontology Biological Process:
- ATP hydrolysis coupled proton transport
cellular potassium ion homeostasis
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
potassium ion import
regulation of pH
response to metal ion
response to organic cyclic compound
sodium ion export from cell
transmembrane transport - Gene Ontology Molecular Function:
- ATP binding
hydrogen:potassium-exchanging ATPase activity
metal ion binding
sodium:potassium-exchanging ATPase activity - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
hydrogen:potassium-exchanging ATPase complex
intracellular membrane-bounded organelle
plasma membrane - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Hydrogen ion transport
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport