Names & Taxonomy

Uniprot ID:
P54707
Entry Name:
AT12A_HUMAN
Status:
reviewed
Protein Names:
Potassium-transporting ATPase alpha chain 2 (EC 3.6.3.10) (Non-gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)
Gene Names:
ATP12A ATP1AL1
Gene Names Primary:
ATP12A
Organism:
Homo sapiens (Human)

Structure

Length:
1039
Sequence:
MHQKTPEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQYSSDKSASLNNVYLGCVLGLVVILTGIFAYYQEAKSTNIMSSFNKMIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESEPQPRSSEFTHENPLETKNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEKTPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSEDHSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILGDVMEIRKRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDAMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANSETVEDIAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWEKDYVNDLKDSYGQEWTRYQREYLEWTGYTAFFVGILVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGITSQIIIGLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEVRKLFIRLYPGSWWDKNMYY
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.
Catalytic Activity:
ATP + H(2)O + H(+)(In) + K(+)(Out) = ADP + phosphate + H(+)(Out) + K(+)(In).
Active Site:
ACT_SITE 391 391 4-aspartylphosphate intermediate.
Gene Ontology Go:
apical plasma membrane
basolateral plasma membrane
hydrogen:potassium-exchanging ATPase complex
intracellular membrane-bounded organelle
plasma membrane
ATP binding
hydrogen:potassium-exchanging ATPase activity
metal ion binding
sodium:potassium-exchanging ATPase activity
ATP hydrolysis coupled proton transport
cellular potassium ion homeostasis
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
potassium ion import
regulation of pH
response to metal ion
response to organic cyclic compound
sodium ion export from cell
transmembrane transport
Gene Ontology Biological Process:
ATP hydrolysis coupled proton transport
cellular potassium ion homeostasis
cellular sodium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
ion transmembrane transport
potassium ion import
regulation of pH
response to metal ion
response to organic cyclic compound
sodium ion export from cell
transmembrane transport
Gene Ontology Molecular Function:
ATP binding
hydrogen:potassium-exchanging ATPase activity
metal ion binding
sodium:potassium-exchanging ATPase activity
Gene Ontology Cellular Component:
apical plasma membrane
basolateral plasma membrane
hydrogen:potassium-exchanging ATPase complex
intracellular membrane-bounded organelle
plasma membrane
Keywords:
ATP-binding
Alternative splicing
Complete proteome
Hydrogen ion transport
Hydrolase
Ion transport
Magnesium
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8045293 8838794 14702039 15057823 15489334 1847115 3035563 3036582 9872395 22179016 24275569