Names & Taxonomy
- Uniprot ID:
- P54687
- Entry Name:
- BCAT1_HUMAN
- Status:
- reviewed
- Protein Names:
- Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) (Protein ECA39)
- Gene Names:
- BCAT1 BCT1 ECA39
- Gene Names Primary:
- BCAT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 386
- Sequence:
- MKDCSNGCSAECTGEGGSKEVVGTFKAKDLIVTPATILKEKPDPNNLVFGTVFTDHMLTVEWSSEFGWEKPHIKPLQNLSLHPGSSALHYAVELFEGLKAFRGVDNKIRLFQPNLNMDRMYRSAVRATLPVFDKEELLECIQQLVKLDQEWVPYSTSASLYIRPTFIGTEPSLGVKKPTKALLFVLLSPVGPYFSSGTFNPVSLWANPKYVRAWKGGTGDCKMGGNYGSSLFAQCEAVDNGCQQVLWLYGEDHQITEVGTMNLFLYWINEDGEEELATPPLDGIILPGVTRRCILDLAHQWGEFKVSERYLTMDDLTTALEGNRVREMFGSGTACVVCPVSDILYKGETIHIPTMENGPKLASRILSKLTDIQYGREESDWTIVLS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
- Catalytic Activity:
- L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.; L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.; L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.
- Cofactor:
- COFACTOR: Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Cross Reference Drug Bank:
- DB00996 DB00167 DB00149 DB00161
- Gene Ontology Go:
- cytosol
branched-chain-amino-acid transaminase activity
L-isoleucine transaminase activity
L-leucine transaminase activity
L-valine transaminase activity
branched-chain amino acid biosynthetic process
branched-chain amino acid catabolic process
cell proliferation
cellular nitrogen compound metabolic process
G1/S transition of mitotic cell cycle
small molecule metabolic process - Gene Ontology Biological Process:
- branched-chain amino acid biosynthetic process
branched-chain amino acid catabolic process
cell proliferation
cellular nitrogen compound metabolic process
G1/S transition of mitotic cell cycle
small molecule metabolic process - Gene Ontology Molecular Function:
- branched-chain-amino-acid transaminase activity
L-isoleucine transaminase activity
L-leucine transaminase activity
L-valine transaminase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Acetylation
Alternative splicing
Amino-acid biosynthesis
Aminotransferase
Branched-chain amino acid biosynthesis
Complete proteome
Cytoplasm
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase