Names & Taxonomy

Uniprot ID:
P54577
Entry Name:
SYYC_HUMAN
Status:
reviewed
Protein Names:
Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed]
Gene Names:
YARS
Gene Names Primary:
YARS
Organism:
Homo sapiens (Human)

Structure

Length:
528
Sequence:
MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Catalytic Activity:
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).
Cross Reference Drug Bank:
DB00135
Gene Ontology Go:
cytoplasm
cytosol
extracellular space
nucleus
ATP binding
interleukin-8 receptor binding
poly(A) RNA binding
signal transducer activity
tRNA binding
tyrosine-tRNA ligase activity
valine-tRNA ligase activity
apoptotic process
gene expression
signal transduction
tRNA aminoacylation for protein translation
tyrosyl-tRNA aminoacylation
Gene Ontology Biological Process:
apoptotic process
gene expression
signal transduction
tRNA aminoacylation for protein translation
tyrosyl-tRNA aminoacylation
Gene Ontology Molecular Function:
ATP binding
interleukin-8 receptor binding
poly(A) RNA binding
signal transducer activity
tRNA binding
tyrosine-tRNA ligase activity
valine-tRNA ligase activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular space
nucleus
Keywords:
3D-structure
ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Charcot-Marie-Tooth disease
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Ligase
Neurodegeneration
Neuropathy
Nucleotide-binding
Polymorphism
Protein biosynthesis
RNA-binding
Reference proteome
tRNA-binding

Publication

PubMed ID:
8552597 9162081 14702039 15489334 12665801 19413330 19608861 21269460 24275569 25944712 12427973 14671330 16429158 24627108