Names & Taxonomy
- Uniprot ID:
- P54577
- Entry Name:
- SYYC_HUMAN
- Status:
- reviewed
- Protein Names:
- Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed]
- Gene Names:
- YARS
- Gene Names Primary:
- YARS
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 528
- Sequence:
- MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
- Catalytic Activity:
- ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).
- Cross Reference Drug Bank:
- DB00135
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular space
nucleus
ATP binding
interleukin-8 receptor binding
poly(A) RNA binding
signal transducer activity
tRNA binding
tyrosine-tRNA ligase activity
valine-tRNA ligase activity
apoptotic process
gene expression
signal transduction
tRNA aminoacylation for protein translation
tyrosyl-tRNA aminoacylation - Gene Ontology Biological Process:
- apoptotic process
gene expression
signal transduction
tRNA aminoacylation for protein translation
tyrosyl-tRNA aminoacylation - Gene Ontology Molecular Function:
- ATP binding
interleukin-8 receptor binding
poly(A) RNA binding
signal transducer activity
tRNA binding
tyrosine-tRNA ligase activity
valine-tRNA ligase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular space
nucleus - Keywords:
- 3D-structure
ATP-binding
Acetylation
Aminoacyl-tRNA synthetase
Charcot-Marie-Tooth disease
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Ligase
Neurodegeneration
Neuropathy
Nucleotide-binding
Polymorphism
Protein biosynthesis
RNA-binding
Reference proteome
tRNA-binding