Names & Taxonomy
- Uniprot ID:
- P53779
- Entry Name:
- MK10_HUMAN
- Status:
- reviewed
- Protein Names:
- Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
- Gene Names:
- MAPK10 JNK3 JNK3A PRKM10 SAPK1B
- Gene Names Primary:
- MAPK10
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 464
- Sequence:
- MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax. MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by HDAC9.
- Active Site:
- ACT_SITE 189 189 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
cytosol
mitochondrion
nucleoplasm
plasma membrane
ATP binding
JUN kinase activity
MAP kinase kinase activity
activation of MAPK activity
Fc-epsilon receptor signaling pathway
innate immune response
JNK cascade
JUN phosphorylation
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
protein phosphorylation
regulation of circadian rhythm
regulation of sequence-specific DNA binding transcription factor activity
response to light stimulus
rhythmic process
signal transduction
stress-activated MAPK cascade
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
TRIF-dependent toll-like receptor signaling pathway - Gene Ontology Biological Process:
- activation of MAPK activity
Fc-epsilon receptor signaling pathway
innate immune response
JNK cascade
JUN phosphorylation
MyD88-dependent toll-like receptor signaling pathway
MyD88-independent toll-like receptor signaling pathway
protein phosphorylation
regulation of circadian rhythm
regulation of sequence-specific DNA binding transcription factor activity
response to light stimulus
rhythmic process
signal transduction
stress-activated MAPK cascade
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
TRIF-dependent toll-like receptor signaling pathway - Gene Ontology Molecular Function:
- ATP binding
JUN kinase activity
MAP kinase kinase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
mitochondrion
nucleoplasm
plasma membrane - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Biological rhythms
Chromosomal rearrangement
Complete proteome
Cytoplasm
Direct protein sequencing
Epilepsy
Kinase
Lipoprotein
Membrane
Mental retardation
Mitochondrion
Nucleotide-binding
Nucleus
Palmitate
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Transferase - Interacts With:
- P49407; P05412; Q04206