Names & Taxonomy

Uniprot ID:
P53708
Entry Name:
ITA8_HUMAN
Status:
reviewed
Protein Names:
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]
Gene Names:
ITGA8
Gene Names Primary:
ITGA8
Organism:
Homo sapiens (Human)

Structure

Length:
1063
Sequence:
MSPGASRGPRGSQAPLIAPLCCAAAALGMLLWSPACQAFNLDVEKLTVYSGPKGSYFGYAVDFHIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPAEGSAQCRQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVKAHKGKVVACAPLYHWRTLKPTPEKDPVGTCYVAIQNFSAYAEFSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGPGSFYWQGQVITASVADIIANYSFKDILRKLAGEKQTEVAPASYDDSYLGYSVAAGEFTGDSQQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNSDGLDDVLVGAPLFMEREFESNPREVGQIYLYLQVSSLLFRDPQILTGTETFGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNKDGLNTKPSQVLQGVWASHAVPSGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQVPDSMTSAACFSLRVCASVTGQSIANTIVLMAEVQLDSLKQKGAIKRTLFLDNHQAHRVFPLVIKRQKSHQCQDFIVYLRDETEFRDKLSPINISLNYSLDESTFKEGLEVKPILNYYRENIVSEQAHILVDCGEDNLCVPDLKLSARPDKHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIERNNKGFRPLSCEYKMENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPPQIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEFLLYIFHIQTLGPLQCQPNPNINPQDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQRKNDPYALASLVSFEVKKMPYTDQPAKLPEGSIVIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFDRARPPQEDMTDREQLTNDKTPEA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
Gene Ontology Go:
apical part of cell
cell surface
dendritic spine membrane
endoplasmic reticulum
focal adhesion
integrin alpha8-beta1 complex
integrin complex
perikaryon
plasma membrane
postsynaptic density
metal ion binding
brain development
cell projection organization
cell-matrix adhesion
establishment of protein localization
extracellular matrix organization
inner ear morphogenesis
integrin-mediated signaling pathway
kidney development
memory
mesodermal cell differentiation
metanephros development
positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
positive regulation of transforming growth factor beta receptor signaling pathway
single organismal cell-cell adhesion
smooth muscle tissue development
substrate adhesion-dependent cell spreading
Gene Ontology Biological Process:
brain development
cell-matrix adhesion
cell projection organization
establishment of protein localization
extracellular matrix organization
inner ear morphogenesis
integrin-mediated signaling pathway
kidney development
memory
mesodermal cell differentiation
metanephros development
positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
positive regulation of transforming growth factor beta receptor signaling pathway
single organismal cell-cell adhesion
smooth muscle tissue development
substrate adhesion-dependent cell spreading
Gene Ontology Molecular Function:
metal ion binding
Gene Ontology Cellular Component:
apical part of cell
cell surface
dendritic spine membrane
endoplasmic reticulum
focal adhesion
integrin alpha8-beta1 complex
integrin complex
perikaryon
plasma membrane
postsynaptic density
Keywords:
Calcium
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Developmental protein
Differentiation
Disease mutation
Disulfide bond
Glycoprotein
Integrin
Membrane
Metal-binding
Neurogenesis
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
15164054 7768999 10504498 12415008 15721307 24439109 15579315