Names & Taxonomy

Uniprot ID:
P52961
Entry Name:
NAR1_HUMAN
Status:
reviewed
Protein Names:
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 (EC 2.4.2.31) (ADP-ribosyltransferase C2 and C3 toxin-like 1) (ARTC1) (Mono(ADP-ribosyl)transferase 1) (CD antigen CD296)
Gene Names:
ART1
Gene Names Primary:
ART1
Organism:
Homo sapiens (Human)

Structure

Length:
327
Sequence:
MQMPAMMSLLLVSVGLMEALQAQSHPITRRDLFSQEIQLDMALASFDDQYAGCAAAMTAALPDLNHTEFQANQVYADSWTLASSQWQERQARWPEWSLSPTRPSPPPLGFRDEHGVALLAYTANSPLHKEFNAAVREAGRSRAHYLHHFSFKTLHFLLTEALQLLGSGQRPPRCHQVFRGVHGLRFRPAGPRATVRLGGFASASLKHVAAQQFGEDTFFGIWTCLGAPIKGYSFFPGEEEVLIPPFETFQVINASRLAQGPARIYLRALGKHSTYNCEYIKDKKCKSGPCHLDNSAMGQSPLSAVWSLLLLLWFLVVRAFPDGPGLL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Sarcoplasmic reticulum membrane; Lipid-anchor, GPI-anchor.

Function

Function:
Has ADP-ribosyltransferase activity toward GLP1R.
Catalytic Activity:
NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.
Active Site:
ACT_SITE 247 247
Gene Ontology Go:
anchored component of membrane
cell surface
integral component of plasma membrane
plasma membrane
sarcoplasmic reticulum membrane
NAD(P)+-protein-arginine ADP-ribosyltransferase activity
NAD+ ADP-ribosyltransferase activity
innate immune response
protein ADP-ribosylation
Gene Ontology Biological Process:
innate immune response
protein ADP-ribosylation
Gene Ontology Molecular Function:
NAD(P)+-protein-arginine ADP-ribosyltransferase activity
NAD+ ADP-ribosyltransferase activity
Gene Ontology Cellular Component:
anchored component of membrane
cell surface
integral component of plasma membrane
plasma membrane
sarcoplasmic reticulum membrane
Keywords:
Complete proteome
Disulfide bond
GPI-anchor
Glycoprotein
Glycosyltransferase
Lipoprotein
Membrane
NAD
NADP
Polymorphism
Reference proteome
Sarcoplasmic reticulum
Signal
Transferase

Publication

PubMed ID:
7947688 15489334 20106667 21901419