Names & Taxonomy
- Uniprot ID:
- P52758
- Entry Name:
- UK114_HUMAN
- Status:
- reviewed
- Protein Names:
- Ribonuclease UK114 (EC 3.1.-.-) (14.5 kDa translational inhibitor protein) (p14.5) (Heat-responsive protein 12) (UK114 antigen homolog)
- Gene Names:
- HRSP12 PSP
- Gene Names Primary:
- HRSP12
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 137
- Sequence:
- MSSLIRRVISTAKAPGAIGPYSQAVLVDRTIYISGQIGMDPSSGQLVSGGVAEEAKQALKNMGEILKAAGCDFTNVVKTTVLLADINDFNTVNEIYKQYFKSNFPARAAYQVAALPKGSRIEIEAVAIQGPLTTASL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus. Note=Mostly cytoplasmic but, in less differentiated cells occasionally nuclear.
Function
- Function:
- Endoribonuclease responsible for the inhibition of the translation by cleaving mRNA. Inhibits cell-free protein synthesis. Cleaves phosphodiester bonds only in single-stranded RNA (By similarity).
- Cross Reference Drug Bank:
- DB03793
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
nucleus
peroxisome
endoribonuclease activity, producing 3'-phosphomonoesters
long-chain fatty acid binding
platinum binding
poly(A) RNA binding
transition metal ion binding
xenon atom binding
brain development
G1 to G0 transition
kidney development
lung development
negative regulation of epithelial cell proliferation
negative regulation of translation
regulation of translational termination
response to lipid
response to salt - Gene Ontology Biological Process:
- brain development
G1 to G0 transition
kidney development
lung development
negative regulation of epithelial cell proliferation
negative regulation of translation
regulation of translational termination
response to lipid
response to salt - Gene Ontology Molecular Function:
- endoribonuclease activity, producing 3'-phosphomonoesters
long-chain fatty acid binding
platinum binding
poly(A) RNA binding
transition metal ion binding
xenon atom binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
mitochondrion
nucleus
peroxisome - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Endonuclease
Hydrolase
Nuclease
Nucleus
Phosphoprotein
Reference proteome