Names & Taxonomy
- Uniprot ID:
- P52732
- Entry Name:
- KIF11_HUMAN
- Status:
- reviewed
- Protein Names:
- Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5)
- Gene Names:
- KIF11 EG5 KNSL1 TRIP5
- Gene Names Primary:
- KIF11
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1056
- Sequence:
- MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).
- Gene Ontology Go:
- cytoplasm
cytosol
kinesin complex
membrane
microtubule
spindle
spindle pole
ATP binding
ATP-dependent microtubule motor activity, plus-end-directed
microtubule motor activity
protein complex binding
protein kinase binding
antigen processing and presentation of exogenous peptide antigen via MHC class II
blood coagulation
cell division
chromosome segregation
microtubule-based movement
mitotic centrosome separation
mitotic nuclear division
mitotic spindle assembly
mitotic spindle organization
regulation of mitotic centrosome separation
spindle organization - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class II
blood coagulation
cell division
chromosome segregation
microtubule-based movement
mitotic centrosome separation
mitotic nuclear division
mitotic spindle assembly
mitotic spindle organization
regulation of mitotic centrosome separation
spindle organization - Gene Ontology Molecular Function:
- ATP binding
ATP-dependent microtubule motor activity, plus-end-directed
microtubule motor activity
protein complex binding
protein kinase binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
kinesin complex
membrane
microtubule
spindle
spindle pole - Keywords:
- 3D-structure
ATP-binding
Acetylation
Cell cycle
Cell division
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Microtubule
Mitosis
Motor protein
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome