Names & Taxonomy

Uniprot ID:
P52732
Entry Name:
KIF11_HUMAN
Status:
reviewed
Protein Names:
Kinesin-like protein KIF11 (Kinesin-like protein 1) (Kinesin-like spindle protein HKSP) (Kinesin-related motor protein Eg5) (Thyroid receptor-interacting protein 5) (TR-interacting protein 5) (TRIP-5)
Gene Names:
KIF11 EG5 KNSL1 TRIP5
Gene Names Primary:
KIF11
Organism:
Homo sapiens (Human)

Structure

Length:
1056
Sequence:
MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEYITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNSLFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHVSQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKTSLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFSQELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNEREQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).
Gene Ontology Go:
cytoplasm
cytosol
kinesin complex
membrane
microtubule
spindle
spindle pole
ATP binding
ATP-dependent microtubule motor activity, plus-end-directed
microtubule motor activity
protein complex binding
protein kinase binding
antigen processing and presentation of exogenous peptide antigen via MHC class II
blood coagulation
cell division
chromosome segregation
microtubule-based movement
mitotic centrosome separation
mitotic nuclear division
mitotic spindle assembly
mitotic spindle organization
regulation of mitotic centrosome separation
spindle organization
Gene Ontology Biological Process:
antigen processing and presentation of exogenous peptide antigen via MHC class II
blood coagulation
cell division
chromosome segregation
microtubule-based movement
mitotic centrosome separation
mitotic nuclear division
mitotic spindle assembly
mitotic spindle organization
regulation of mitotic centrosome separation
spindle organization
Gene Ontology Molecular Function:
ATP binding
ATP-dependent microtubule motor activity, plus-end-directed
microtubule motor activity
protein complex binding
protein kinase binding
Gene Ontology Cellular Component:
cytoplasm
cytosol
kinesin complex
membrane
microtubule
spindle
spindle pole
Keywords:
3D-structure
ATP-binding
Acetylation
Cell cycle
Cell division
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Disease mutation
Microtubule
Mitosis
Motor protein
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome

Publication

PubMed ID:
8548803 9701554 15164054 15489334 7776974 16964243 17525332 19001501 18669648 19608861 20068231 21269460 21406692 23857769 11328809 17707232 22284827