Names & Taxonomy
- Uniprot ID:
- P51854
- Entry Name:
- TKTL1_HUMAN
- Status:
- reviewed
- Protein Names:
- Transketolase-like protein 1 (EC 2.2.1.1) (Transketolase 2) (TK 2) (Transketolase-related protein)
- Gene Names:
- TKTL1 TKR TKT2
- Gene Names Primary:
- TKTL1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 596
- Sequence:
- MADAEARAEFPEEARPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVLFFYIMRYKQSDPENPDNDRFVLAKRLSFVDVATGWLGQGLGVACGMAYTGKYFDRASYRVFCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCINIYQRRCEAFGWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPMPRERADAIIKLIESQIQTSRNLDPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGLALAKLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFASTFAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIFYPTDAVSTEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVIGAGITVYEALAAADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCMLLN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
- Catalytic Activity:
- Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 340 340 Proton donor.
- Gene Ontology Go:
- cytoplasm
nucleus
metal ion binding
transketolase activity
glucose catabolic process
thiamine metabolic process - Gene Ontology Biological Process:
- glucose catabolic process
thiamine metabolic process - Gene Ontology Molecular Function:
- metal ion binding
transketolase activity - Gene Ontology Cellular Component:
- cytoplasm
nucleus - Keywords:
- Alternative splicing
Calcium
Complete proteome
Cytoplasm
Magnesium
Metal-binding
Nucleus
Polymorphism
Reference proteome
Thiamine pyrophosphate
Transferase