Names & Taxonomy
- Uniprot ID:
- P51800
- Entry Name:
- CLCKA_HUMAN
- Status:
- reviewed
- Protein Names:
- Chloride channel protein ClC-Ka (Chloride channel Ka) (ClC-K1)
- Gene Names:
- CLCNKA
- Gene Names Primary:
- CLCNKA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 687
- Sequence:
- MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLMALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLVQALQAEPPSRAPGHQQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTNPPAPK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
- Enzyme Regulation:
- ENZYME REGULATION: Activated by extracellular calcium and inhibited by extracellular protons.
- Cross Reference Drug Bank:
- DB04552
- Gene Ontology Go:
- chloride channel complex
integral component of plasma membrane
plasma membrane
metal ion binding
voltage-gated chloride channel activity
excretion
ion transmembrane transport
regulation of anion transmembrane transport
transmembrane transport
transport - Gene Ontology Biological Process:
- excretion
ion transmembrane transport
regulation of anion transmembrane transport
transmembrane transport
transport - Gene Ontology Molecular Function:
- metal ion binding
voltage-gated chloride channel activity - Gene Ontology Cellular Component:
- chloride channel complex
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Bartter syndrome
CBS domain
Calcium
Chloride
Chloride channel
Complete proteome
Deafness
Disease mutation
Ion channel
Ion transport
Membrane
Metal-binding
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel