Names & Taxonomy

Uniprot ID:
P51788
Entry Name:
CLCN2_HUMAN
Status:
reviewed
Protein Names:
Chloride channel protein 2 (ClC-2)
Gene Names:
CLCN2
Gene Names Primary:
CLCN2
Organism:
Homo sapiens (Human)

Structure

Length:
898
Sequence:
MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPELLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQERRATQTSPLSDQEGPPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLGESPTGSAESAGIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGVKVRPPLASFRDSATSSSDTETTEVHALWGPHSRHGLPREGSPSDSDDKCQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane
Intramembrane:
INTRAMEM 164 171 Helical.

Function

Function:
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
Cross Reference Drug Bank:
DB01046
Gene Ontology Go:
chloride channel complex
plasma membrane
voltage-gated chloride channel activity
cell differentiation involved in salivary gland development
ion transmembrane transport
retina development in camera-type eye
transmembrane transport
transport
Gene Ontology Biological Process:
cell differentiation involved in salivary gland development
ion transmembrane transport
retina development in camera-type eye
transmembrane transport
transport
Gene Ontology Molecular Function:
voltage-gated chloride channel activity
Gene Ontology Cellular Component:
chloride channel complex
plasma membrane
Keywords:
Acetylation
Alternative splicing
CBS domain
Cell membrane
Chloride
Chloride channel
Complete proteome
Disease mutation
Epilepsy
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
7795595 14702039 16641997 15489334 10198195 19153159 12612585 19710717 22814378 17762171 19200853 19710712 19191339 23707145