Names & Taxonomy
- Uniprot ID:
- P51692
- Entry Name:
- STA5B_HUMAN
- Status:
- reviewed
- Protein Names:
- Signal transducer and activator of transcription 5B
- Gene Names:
- STAT5B
- Gene Names Primary:
- STAT5B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 787
- Sequence:
- MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription.
- Cross Reference Drug Bank:
- DB01254
- Gene Ontology Go:
- cytoplasm
cytosol
nucleoplasm
nucleus
chromatin binding
glucocorticoid receptor binding
protein dimerization activity
RNA polymerase II core promoter sequence-specific DNA binding
signal transducer activity
transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
2-oxoglutarate metabolic process
acute-phase response
allantoin metabolic process
cellular response to epidermal growth factor stimulus
cellular response to growth factor stimulus
cellular response to hormone stimulus
citrate metabolic process
creatine metabolic process
creatinine metabolic process
development of secondary female sexual characteristics
development of secondary male sexual characteristics
fatty acid metabolic process
female pregnancy
isoleucine metabolic process
JAK-STAT cascade
JAK-STAT cascade involved in growth hormone signaling pathway
lactation
lipid storage
liver development
luteinization
mast cell migration
natural killer cell differentiation
negative regulation of apoptotic process
negative regulation of erythrocyte differentiation
oxaloacetate metabolic process
Peyer's patch development
positive regulation of activated T cell proliferation
positive regulation of B cell differentiation
positive regulation of cellular component movement
positive regulation of gamma-delta T cell differentiation
positive regulation of inflammatory response
positive regulation of interleukin-2 biosynthetic process
positive regulation of mitotic cell cycle
positive regulation of multicellular organism growth
positive regulation of natural killer cell differentiation
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell proliferation
positive regulation of smooth muscle cell proliferation
positive regulation of transcription from RNA polymerase II promoter
progesterone metabolic process
prolactin signaling pathway
regulation of epithelial cell differentiation
regulation of multicellular organism growth
regulation of steroid metabolic process
regulation of transcription from RNA polymerase II promoter
response to estradiol
response to ethanol
response to hypoxia
response to interleukin-15
response to interleukin-2
response to interleukin-4
response to lipopolysaccharide
succinate metabolic process
T cell differentiation in thymus
T cell homeostasis
taurine metabolic process
valine metabolic process - Gene Ontology Biological Process:
- 2-oxoglutarate metabolic process
acute-phase response
allantoin metabolic process
cellular response to epidermal growth factor stimulus
cellular response to growth factor stimulus
cellular response to hormone stimulus
citrate metabolic process
creatine metabolic process
creatinine metabolic process
development of secondary female sexual characteristics
development of secondary male sexual characteristics
fatty acid metabolic process
female pregnancy
isoleucine metabolic process
JAK-STAT cascade
JAK-STAT cascade involved in growth hormone signaling pathway
lactation
lipid storage
liver development
luteinization
mast cell migration
natural killer cell differentiation
negative regulation of apoptotic process
negative regulation of erythrocyte differentiation
oxaloacetate metabolic process
Peyer's patch development
positive regulation of activated T cell proliferation
positive regulation of B cell differentiation
positive regulation of cellular component movement
positive regulation of gamma-delta T cell differentiation
positive regulation of inflammatory response
positive regulation of interleukin-2 biosynthetic process
positive regulation of mitotic cell cycle
positive regulation of multicellular organism growth
positive regulation of natural killer cell differentiation
positive regulation of natural killer cell mediated cytotoxicity
positive regulation of natural killer cell proliferation
positive regulation of smooth muscle cell proliferation
positive regulation of transcription from RNA polymerase II promoter
progesterone metabolic process
prolactin signaling pathway
regulation of epithelial cell differentiation
regulation of multicellular organism growth
regulation of steroid metabolic process
regulation of transcription from RNA polymerase II promoter
response to estradiol
response to ethanol
response to hypoxia
response to interleukin-15
response to interleukin-2
response to interleukin-4
response to lipopolysaccharide
succinate metabolic process
taurine metabolic process
T cell differentiation in thymus
T cell homeostasis
valine metabolic process - Gene Ontology Molecular Function:
- chromatin binding
glucocorticoid receptor binding
protein dimerization activity
RNA polymerase II core promoter sequence-specific DNA binding
signal transducer activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleoplasm
nucleus - Keywords:
- Activator
Complete proteome
Cytoplasm
DNA-binding
Disease mutation
Dwarfism
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
SH2 domain
Transcription
Transcription regulation - Interacts With:
- Q96EY1; Q13287