Names & Taxonomy

Uniprot ID:
P51606
Entry Name:
RENBP_HUMAN
Status:
reviewed
Protein Names:
N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP)
Gene Names:
RENBP
Gene Names Primary:
RENBP
Organism:
Homo sapiens (Human)

Structure

Length:
427
Sequence:
MSKGLPARQDMEKERETLQAWKERVGQELDRVVAFWMEHSHDQEHGGFFTCLGREGRVYDDLKYVWLQGRQVWMYCRLYRTFERFRHAQLLDAAKAGGEFLLRYARVAPPGKKCAFVLTRDGRPVKVQRTIFSECFYTMAMNELWRATGEVRYQTEAVEMMDQIVHWVQEDASGLGRPQLQGAPAAEPMAVPMMLLNLVEQLGEADEELAGKYAELGDWCARRILQHVQRDGQAVLENVSEGGKELPGCLGRQQNPGHTLEAGWFLLRHCIRKGDPELRAHVIDKFLLLPFHSGWDPDHGGLFYFQDADNFCPTQLEWAMKLWWPHSEAMIAFLMGYSDSGDPVLLRLFYQVAEYTFRQFRDPEYGEWFGYLSREGKVALSIKGGPFKGCFHVPRCLAMCEEMLGALLSRPAPAPSPAPTPACRGAE
Proteomes:
UP000005640

Function

Function:
Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
Pathway:
Amino-sugar metabolism; N-acetylneuraminate degradation.
Catalytic Activity:
N-acyl-D-glucosamine = N-acyl-D-mannosamine.
Cross Reference Drug Bank:
DB00141
Gene Ontology Go:
extracellular exosome
ATP binding
endopeptidase inhibitor activity
N-acylglucosamine 2-epimerase activity
N-acetylglucosamine metabolic process
N-acetylmannosamine metabolic process
N-acetylneuraminate catabolic process
regulation of blood pressure
Gene Ontology Biological Process:
N-acetylglucosamine metabolic process
N-acetylmannosamine metabolic process
N-acetylneuraminate catabolic process
regulation of blood pressure
Gene Ontology Molecular Function:
ATP binding
endopeptidase inhibitor activity
N-acylglucosamine 2-epimerase activity
Gene Ontology Cellular Component:
extracellular exosome
Keywords:
Alternative splicing
Complete proteome
Isomerase
Polymorphism
Reference proteome

Publication

PubMed ID:
14702039 15772651 15489334 1723410 9990133 22692205