Names & Taxonomy
- Uniprot ID:
- P51606
- Entry Name:
- RENBP_HUMAN
- Status:
- reviewed
- Protein Names:
- N-acylglucosamine 2-epimerase (AGE) (EC 5.1.3.8) (GlcNAc 2-epimerase) (N-acetyl-D-glucosamine 2-epimerase) (Renin-binding protein) (RnBP)
- Gene Names:
- RENBP
- Gene Names Primary:
- RENBP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 427
- Sequence:
- MSKGLPARQDMEKERETLQAWKERVGQELDRVVAFWMEHSHDQEHGGFFTCLGREGRVYDDLKYVWLQGRQVWMYCRLYRTFERFRHAQLLDAAKAGGEFLLRYARVAPPGKKCAFVLTRDGRPVKVQRTIFSECFYTMAMNELWRATGEVRYQTEAVEMMDQIVHWVQEDASGLGRPQLQGAPAAEPMAVPMMLLNLVEQLGEADEELAGKYAELGDWCARRILQHVQRDGQAVLENVSEGGKELPGCLGRQQNPGHTLEAGWFLLRHCIRKGDPELRAHVIDKFLLLPFHSGWDPDHGGLFYFQDADNFCPTQLEWAMKLWWPHSEAMIAFLMGYSDSGDPVLLRLFYQVAEYTFRQFRDPEYGEWFGYLSREGKVALSIKGGPFKGCFHVPRCLAMCEEMLGALLSRPAPAPSPAPTPACRGAE
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.
- Pathway:
- Amino-sugar metabolism; N-acetylneuraminate degradation.
- Catalytic Activity:
- N-acyl-D-glucosamine = N-acyl-D-mannosamine.
- Cross Reference Drug Bank:
- DB00141
- Gene Ontology Go:
- extracellular exosome
ATP binding
endopeptidase inhibitor activity
N-acylglucosamine 2-epimerase activity
N-acetylglucosamine metabolic process
N-acetylmannosamine metabolic process
N-acetylneuraminate catabolic process
regulation of blood pressure - Gene Ontology Biological Process:
- N-acetylglucosamine metabolic process
N-acetylmannosamine metabolic process
N-acetylneuraminate catabolic process
regulation of blood pressure - Gene Ontology Molecular Function:
- ATP binding
endopeptidase inhibitor activity
N-acylglucosamine 2-epimerase activity - Gene Ontology Cellular Component:
- extracellular exosome
- Keywords:
- Alternative splicing
Complete proteome
Isomerase
Polymorphism
Reference proteome