Names & Taxonomy
- Uniprot ID:
- P51511
- Entry Name:
- MMP15_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrix metalloproteinase-15 (MMP-15) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP-2)
- Gene Names:
- MMP15
- Gene Names Primary:
- MMP15
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 669
- Sequence:
- MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLYCKRSLQEWV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 260 260
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- extracellular matrix
integral component of plasma membrane
plasma membrane
calcium ion binding
enzyme activator activity
metalloendopeptidase activity
zinc ion binding
cellular protein modification process
collagen catabolic process
endodermal cell differentiation
extracellular matrix disassembly
extracellular matrix organization
positive regulation of catalytic activity
response to estradiol - Gene Ontology Biological Process:
- cellular protein modification process
collagen catabolic process
endodermal cell differentiation
extracellular matrix disassembly
extracellular matrix organization
positive regulation of catalytic activity
response to estradiol - Gene Ontology Molecular Function:
- calcium ion binding
enzyme activator activity
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular matrix
integral component of plasma membrane
plasma membrane - Keywords:
- Calcium
Cleavage on pair of basic residues
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Phosphoprotein
Polymorphism
Protease
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Zinc
Zymogen - Interacts With:
- P04070