Names & Taxonomy

Uniprot ID:
P51178
Entry Name:
PLCD1_HUMAN
Status:
reviewed
Protein Names:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)
Gene Names:
PLCD1
Gene Names Primary:
PLCD1
Organism:
Homo sapiens (Human)

Structure

Length:
756
Sequence:
MDSGRDFLTLHGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD
Proteomes:
UP000005640

Function

Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.
Catalytic Activity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Active Site:
ACT_SITE 311 311
Gene Ontology Go:
cytoplasm
cytosol
extracellular exosome
plasma membrane
calcium ion binding
GTPase activating protein binding
phosphatidic acid binding
phosphatidylinositol phosphate binding
phosphatidylinositol phospholipase C activity
phosphatidylserine binding
signal transducer activity
angiogenesis
inositol phosphate metabolic process
intracellular signal transduction
labyrinthine layer blood vessel development
lipid catabolic process
phospholipid metabolic process
regulation of cell proliferation
small molecule metabolic process
Gene Ontology Biological Process:
angiogenesis
inositol phosphate metabolic process
intracellular signal transduction
labyrinthine layer blood vessel development
lipid catabolic process
phospholipid metabolic process
regulation of cell proliferation
small molecule metabolic process
Gene Ontology Molecular Function:
calcium ion binding
GTPase activating protein binding
phosphatidic acid binding
phosphatidylinositol phosphate binding
phosphatidylinositol phospholipase C activity
phosphatidylserine binding
signal transducer activity
Gene Ontology Cellular Component:
cytoplasm
cytosol
extracellular exosome
plasma membrane
Keywords:
Alternative splicing
Calcium
Complete proteome
Disease mutation
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transducer

Publication

PubMed ID:
7890667 14702039 16641997 15489334 24275569 21665001