Names & Taxonomy
- Uniprot ID:
- P51178
- Entry Name:
- PLCD1_HUMAN
- Status:
- reviewed
- Protein Names:
- 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)
- Gene Names:
- PLCD1
- Gene Names Primary:
- PLCD1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 756
- Sequence:
- MDSGRDFLTLHGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD
- Proteomes:
- UP000005640
Function
- Function:
- The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development.
- Catalytic Activity:
- 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 311 311
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
plasma membrane
calcium ion binding
GTPase activating protein binding
phosphatidic acid binding
phosphatidylinositol phosphate binding
phosphatidylinositol phospholipase C activity
phosphatidylserine binding
signal transducer activity
angiogenesis
inositol phosphate metabolic process
intracellular signal transduction
labyrinthine layer blood vessel development
lipid catabolic process
phospholipid metabolic process
regulation of cell proliferation
small molecule metabolic process - Gene Ontology Biological Process:
- angiogenesis
inositol phosphate metabolic process
intracellular signal transduction
labyrinthine layer blood vessel development
lipid catabolic process
phospholipid metabolic process
regulation of cell proliferation
small molecule metabolic process - Gene Ontology Molecular Function:
- calcium ion binding
GTPase activating protein binding
phosphatidic acid binding
phosphatidylinositol phosphate binding
phosphatidylinositol phospholipase C activity
phosphatidylserine binding
signal transducer activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
plasma membrane - Keywords:
- Alternative splicing
Calcium
Complete proteome
Disease mutation
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transducer