Names & Taxonomy

Uniprot ID:
P51170
Entry Name:
SCNNG_HUMAN
Status:
reviewed
Protein Names:
Amiloride-sensitive sodium channel subunit gamma (Epithelial Na(+) channel subunit gamma) (ENaCG) (Gamma-ENaC) (Gamma-NaCH) (Nonvoltage-gated sodium channel 1 subunit gamma) (SCNEG)
Gene Names:
SCNN1G
Gene Names Primary:
SCNN1G
Organism:
Homo sapiens (Human)

Structure

Length:
649
Sequence:
MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSFYTVSVSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTLRLERAFSNQLTDTQMLDEL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Apical cell membrane

Function

Function:
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Enzyme Regulation:
ENZYME REGULATION: Activated by WNK1, WNK2, WNK3 and WNK4.
Cross Reference Drug Bank:
DB00594 DB00384
Gene Ontology Go:
apical plasma membrane
external side of plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
sodium channel complex
ion channel activity
ligand-gated sodium channel activity
sodium channel activity
WW domain binding
excretion
ion transmembrane transport
multicellular organismal water homeostasis
response to stimulus
sensory perception of taste
sodium ion homeostasis
sodium ion transmembrane transport
sodium ion transport
transmembrane transport
Gene Ontology Biological Process:
excretion
ion transmembrane transport
multicellular organismal water homeostasis
response to stimulus
sensory perception of taste
sodium ion homeostasis
sodium ion transmembrane transport
sodium ion transport
transmembrane transport
Gene Ontology Molecular Function:
ion channel activity
ligand-gated sodium channel activity
sodium channel activity
WW domain binding
Gene Ontology Cellular Component:
apical plasma membrane
external side of plasma membrane
extracellular exosome
integral component of plasma membrane
plasma membrane
sodium channel complex
Keywords:
Cell membrane
Complete proteome
Glycoprotein
Ion channel
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sensory transduction
Sodium
Sodium channel
Sodium transport
Taste
Transmembrane
Transmembrane helix
Transport
Ubl conjugation
Interacts With:
P37088

Publication

PubMed ID:
7490094 7762608 12107247 15489334 8824247 7550319 9169421 11244092 12167593 18650438 19017867 22207244 22493497 24124190 23547933 26772908 10404817 10391210 16959974 18507830