Names & Taxonomy
- Uniprot ID:
- P51161
- Entry Name:
- FABP6_HUMAN
- Status:
- reviewed
- Protein Names:
- Gastrotropin (GT) (Fatty acid-binding protein 6) (Ileal lipid-binding protein) (ILBP) (Intestinal 15 kDa protein) (I-15P) (Intestinal bile acid-binding protein) (I-BABP)
- Gene Names:
- FABP6 ILBP ILLBP
- Gene Names Primary:
- FABP6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 128
- Sequence:
- MAFTGKFEMESEKNYDEFMKLLGISSDVIEKARNFKIVTEVQQDGQDFTWSQHYSGGHTMTNKFTVGKESNIQTMGGKTFKATVQMEGGKLVVNFPNYHQTSEIVGDKLVEVSTIGGVTYERVSKRLA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cytoplasm
Function
- Function:
- Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity).
- Cross Reference Drug Bank:
- DB02659
- Gene Ontology Go:
- cytoplasm
cytosol
bile acid binding
lipid binding
transporter activity
bile acid and bile salt transport
bile acid metabolic process
lipid metabolic process
negative regulation of cell proliferation
small molecule metabolic process
triglyceride catabolic process - Gene Ontology Biological Process:
- bile acid and bile salt transport
bile acid metabolic process
lipid metabolic process
negative regulation of cell proliferation
small molecule metabolic process
triglyceride catabolic process - Gene Ontology Molecular Function:
- bile acid binding
lipid binding
transporter activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- 3D-structure
Acetylation
Alternative promoter usage
Complete proteome
Cytoplasm
Lipid transport
Lipid-binding
Membrane
Polymorphism
Reference proteome
Transport