Names & Taxonomy

Uniprot ID:
P50406
Entry Name:
5HT6R_HUMAN
Status:
reviewed
Protein Names:
5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (Serotonin receptor 6)
Gene Names:
HTR6
Gene Names Primary:
HTR6
Organism:
Homo sapiens (Human)

Structure

Length:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).
Cross Reference Drug Bank:
DB00321 DB00543 DB01238 DB06216 DB00477 DB00363 DB01142 DB01049 DB04946 DB00458 DB00408 DB06148 DB00540 DB00334 DB01224 DB06144 DB00246
Gene Ontology Go:
cilium
integral component of plasma membrane
plasma membrane
G-protein coupled serotonin receptor activity
histamine receptor activity
cerebral cortex cell migration
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of TOR signaling
synaptic transmission
Gene Ontology Biological Process:
cerebral cortex cell migration
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of TOR signaling
synaptic transmission
Gene Ontology Molecular Function:
G-protein coupled serotonin receptor activity
histamine receptor activity
Gene Ontology Cellular Component:
cilium
integral component of plasma membrane
plasma membrane
Keywords:
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Membrane
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix
Interacts With:
P06241

Publication

PubMed ID:
8522988 16710414 15489334 7656980 23027611