Names & Taxonomy
- Uniprot ID:
- P50135
- Entry Name:
- HNMT_HUMAN
- Status:
- reviewed
- Protein Names:
- Histamine N-methyltransferase (HMT) (EC 2.1.1.8)
- Gene Names:
- HNMT
- Gene Names Primary:
- HNMT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 292
- Sequence:
- MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIGGGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETSSEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLLWDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
- Catalytic Activity:
- S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.
- Cross Reference Drug Bank:
- DB00613 DB00878 DB00667 DB01103
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
neuron projection
nucleoplasm
histamine N-methyltransferase activity
brain development
cellular nitrogen compound metabolic process
histidine catabolic process
hyperosmotic response
methylation
positive regulation of protein targeting to mitochondrion
respiratory gaseous exchange
response to amine
response to cocaine
response to glucocorticoid
response to immobilization stress
response to interleukin-1
response to tumor cell
selenium compound metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- brain development
cellular nitrogen compound metabolic process
histidine catabolic process
hyperosmotic response
methylation
positive regulation of protein targeting to mitochondrion
respiratory gaseous exchange
response to amine
response to cocaine
response to glucocorticoid
response to immobilization stress
response to interleukin-1
response to tumor cell
selenium compound metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- histamine N-methyltransferase activity
- Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
neuron projection
nucleoplasm - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Methyltransferase
Polymorphism
Reference proteome
S-adenosyl-L-methionine
Transferase