Names & Taxonomy
- Uniprot ID:
- P49888
- Entry Name:
- ST1E1_HUMAN
- Status:
- reviewed
- Protein Names:
- Estrogen sulfotransferase (EC 2.8.2.4) (EST-1) (Sulfotransferase 1E1) (ST1E1) (Sulfotransferase, estrogen-preferring)
- Gene Names:
- SULT1E1 STE
- Gene Names Primary:
- SULT1E1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 294
- Sequence:
- MNSELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTVALNEKFDKHYEQQMKESTLKFRTEI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.
- Catalytic Activity:
- 3'-phosphoadenylyl sulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate.
- Active Site:
- ACT_SITE 107 107 Proton acceptor.
- Cross Reference Drug Bank:
- DB00316 DB01176
- Gene Ontology Go:
- cytosol
estrone sulfotransferase activity
flavonol 3-sulfotransferase activity
steroid binding
steroid sulfotransferase activity
sulfotransferase activity
3'-phosphoadenosine 5'-phosphosulfate metabolic process
estrogen metabolic process
positive regulation of fat cell differentiation
small molecule metabolic process
steroid metabolic process
sulfation
xenobiotic metabolic process - Gene Ontology Biological Process:
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
estrogen metabolic process
positive regulation of fat cell differentiation
small molecule metabolic process
steroid metabolic process
sulfation
xenobiotic metabolic process - Gene Ontology Molecular Function:
- estrone sulfotransferase activity
flavonol 3-sulfotransferase activity
steroid binding
steroid sulfotransferase activity
sulfotransferase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Lipid-binding
Polymorphism
Reference proteome
Steroid-binding
Transferase - Interacts With:
- O76083