Names & Taxonomy
- Uniprot ID:
- P49765
- Entry Name:
- VEGFB_HUMAN
- Status:
- reviewed
- Protein Names:
- Vascular endothelial growth factor B (VEGF-B) (VEGF-related factor) (VRF)
- Gene Names:
- VEGFB VRF
- Gene Names Primary:
- VEGFB
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 207
- Sequence:
- MSPLLRRLLLAALLQLAPAQAPVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Function
- Function:
- Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
- Cross Reference Drug Bank:
- DB08885
- Gene Ontology Go:
- extracellular region
extracellular space
membrane
platelet alpha granule lumen
chemoattractant activity
heparin binding
vascular endothelial growth factor receptor 1 binding
angiogenesis
blood coagulation
cardiac muscle contraction
coronary vasculature development
induction of positive chemotaxis
negative regulation of apoptotic process
negative regulation of gene expression
negative regulation of neuron apoptotic process
platelet activation
platelet degranulation
positive chemotaxis
positive regulation of cell division
positive regulation of endothelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of mast cell chemotaxis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein kinase B signaling
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of vascular wound healing
protein O-linked glycosylation
response to drug
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Biological Process:
- angiogenesis
blood coagulation
cardiac muscle contraction
coronary vasculature development
induction of positive chemotaxis
negative regulation of apoptotic process
negative regulation of gene expression
negative regulation of neuron apoptotic process
platelet activation
platelet degranulation
positive chemotaxis
positive regulation of cell division
positive regulation of endothelial cell proliferation
positive regulation of ERK1 and ERK2 cascade
positive regulation of mast cell chemotaxis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein kinase B signaling
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of vascular wound healing
protein O-linked glycosylation
response to drug
vascular endothelial growth factor receptor signaling pathway - Gene Ontology Molecular Function:
- chemoattractant activity
heparin binding
vascular endothelial growth factor receptor 1 binding - Gene Ontology Cellular Component:
- extracellular region
extracellular space
membrane
platelet alpha granule lumen - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Growth factor
Heparin-binding
Mitogen
Reference proteome
Secreted
Signal