Names & Taxonomy
- Uniprot ID:
- P49759
- Entry Name:
- CLK1_HUMAN
- Status:
- reviewed
- Protein Names:
- Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)
- Gene Names:
- CLK1 CLK
- Gene Names Primary:
- CLK1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 484
- Sequence:
- MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Enzyme Regulation:
- ENZYME REGULATION: Regulates splicing of its own pre-mRNA according to its kinase activity; increased expression of the catalytically active form influences splicing to generate the catalytically inactive splicing variant lacking the kinase domain. Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins (By similarity).
- Active Site:
- ACT_SITE 288 288 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
nucleus
ATP binding
non-membrane spanning protein tyrosine kinase activity
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
cell proliferation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
protein autophosphorylation
regulation of RNA splicing - Gene Ontology Biological Process:
- cell proliferation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
protein autophosphorylation
regulation of RNA splicing - Gene Ontology Molecular Function:
- ATP binding
non-membrane spanning protein tyrosine kinase activity
protein serine/threonine/tyrosine kinase activity
protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- cytoplasm
nucleus - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Complete proteome
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Tyrosine-protein kinase - Interacts With:
- P60409; O76083