Names & Taxonomy

Uniprot ID:
P49366
Entry Name:
DHYS_HUMAN
Status:
reviewed
Protein Names:
Deoxyhypusine synthase (DHS) (EC 2.5.1.46)
Gene Names:
DHPS DS
Gene Names Primary:
DHPS
Organism:
Homo sapiens (Human)

Structure

Length:
369
Sequence:
MEGSLEREAPAGALAAVLKHSSTLPPESTQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQVNAMIEKKLEPLSQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYCKFEDWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKNHIPVFSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRVDAQPVKVYADASLVFPLLVAETFAQKMDAFMHEKNED
Proteomes:
UP000005640

Function

Function:
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
Pathway:
Protein modification; eIF5A hypusination.
Catalytic Activity:
-lysine + spermidine = -deoxyhypusine + propane-1,3-diamine.
Cofactor:
COFACTOR: Name=NAD(+); Xref=ChEBI:CHEBI:57540;
Active Site:
ACT_SITE 329 329 Nucleophile.
Gene Ontology Go:
cytosol
deoxyhypusine synthase activity
cellular protein metabolic process
deoxyhypusine biosynthetic process from spermidine
glucose homeostasis
peptidyl-lysine modification to peptidyl-hypusine
positive regulation of cell proliferation
positive regulation of T cell proliferation
post-translational protein modification
protein homotetramerization
translation
Gene Ontology Biological Process:
cellular protein metabolic process
deoxyhypusine biosynthetic process from spermidine
glucose homeostasis
peptidyl-lysine modification to peptidyl-hypusine
positive regulation of cell proliferation
positive regulation of T cell proliferation
post-translational protein modification
protein homotetramerization
translation
Gene Ontology Molecular Function:
deoxyhypusine synthase activity
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Hypusine biosynthesis
NAD
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Interacts With:
P63241; Q9GZV4; P27361; Q9GZT8; Q6ZVK8; Q9HD43; O00194; Q04864; P32969; Q7L8A9; Q96HA8; P52744-2

Publication

PubMed ID:
7673224 8549832 8615810 9666110 9110174 14702039 15057824 15489334 7750572 9405486 11311149 17525332 20068231 21269460 9493264 15100216