Names & Taxonomy
- Uniprot ID:
- P49327
- Entry Name:
- FAS_HUMAN
- Status:
- reviewed
- Protein Names:
- Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]
- Gene Names:
- FASN FAS
- Gene Names Primary:
- FASN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 2511
- Sequence:
- MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRWKAGLYGLPRRSGKLKDLSRFDASFFGVHPKQAHTMDPQLRLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSEALSRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIALDTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNTSVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTKKSLARRVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIRSLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALCATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGLWAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPRLLRASGRTPEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRGYAVLGGERGGPEVQQVPAGERPLWFICSGMGTQWRGMGLSLMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFDDIVHSFVSLTAIQIGLIDLLSCMGLRPDGIVGHSLGEVACGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGLSWEECKQRCPPGVVPACHNSKDTVTISGPQAPVFEFVEQLRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIREPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSPVLFQEALWHVPEHAVVLEIAPHALLQAVLKRGLKPSCTIIPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVEFPAPRGTPLISPLIKWDHSLAWDVPAAEDFPNGSGSPSAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTPNPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDTMLQMSILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVHISGLHTESAPRRQQEQQVPILEKFCFTPHTEEGCLSERAALQEELQLCKGLVQALQTKVTQQGLKMVVPGLDGAQIPRDPSQQELPRLLSAACRLQLNGNLQLELAQVLAQERPKLPEDPLLSGLLDSPALKACLDTAVENMPSLKMKVVEVLAGHGHLYSRIPGLLSPHPLLQLSYTATDRHPQALEAAQAELQQHDVAQGQWDPADPAPSALGSADLLVCNCAVAALGDPASALSNMVAALREGGFLLLHTLLRGHPLGDIVAFLTSTEPQYGQGILSQDAWESLFSRVSLRLVGLKKSFYGSTLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSRPVWLKAINCATSGVVGLVNCLRREPGGNRLRCVLLSNLSSTSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNESSADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGAIGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLAEKAAAYRDRDSQRDLVEAVAHILGIRDLAAVNLDSSLADLGLDSLMSVEVRQTLERELNLVLSVREVRQLTLRKLQELSSKADEASELACPTPKEDGLAQQQTQLNLRSLLVNPEGPTLMRLNSVQSSERPLFLVHPIEGSTTVFHSLASRLSIPTYGLQCTRAAPLDSIHSLAAYYIDCIRQVQPEGPYRVAGYSYGACVAFEMCSQLQAQQSPAPTHNSLFLFDGSPTYVLAYTQSYRAKLTPGCEAEAETEAICFFVQQFTDMEHNRVLEALLPLKGLEERVAAAVDLIIKSHQGLDRQELSFAARSFYYKLRAAEQYTPKAKYHGNVMLLRAKTGGAYGEDLGADYNLSQVCDGKVSVHVIEGDHRTLLEGSGLESIISIIHSSLAEPRVSVREG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
- Catalytic Activity:
- Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+).
- Active Site:
- ACT_SITE 161 161 For beta-ketoacyl synthase activity.
- Cross Reference Drug Bank:
- DB01034 DB01083
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
glycogen granule
Golgi apparatus
melanosome
membrane
mitochondrion
plasma membrane
3-hydroxyoctanoyl- dehydratase activity
3-hydroxypalmitoyl- dehydratase activity
3-oxoacyl- reductase (NADPH) activity
3-oxoacyl- synthase activity
S-acetyltransferase activity
S-malonyltransferase activity
drug binding
enoyl- reductase (NADPH, A-specific) activity
enoyl- reductase (NADPH, B-specific) activity
fatty acid synthase activity
myristoyl- hydrolase activity
NADPH binding
oleoyl- hydrolase activity
palmitoyl- hydrolase activity
poly(A) RNA binding
acetyl-CoA metabolic process
cellular lipid metabolic process
cellular response to interleukin-4
energy reserve metabolic process
fatty acid biosynthetic process
fatty acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
mammary gland development
osteoblast differentiation
pantothenate metabolic process
positive regulation of cellular metabolic process
small molecule metabolic process
triglyceride biosynthetic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Biological Process:
- acetyl-CoA metabolic process
cellular lipid metabolic process
cellular response to interleukin-4
energy reserve metabolic process
fatty acid biosynthetic process
fatty acid metabolic process
long-chain fatty-acyl-CoA biosynthetic process
mammary gland development
osteoblast differentiation
pantothenate metabolic process
positive regulation of cellular metabolic process
small molecule metabolic process
triglyceride biosynthetic process
vitamin metabolic process
water-soluble vitamin metabolic process - Gene Ontology Molecular Function:
- S-acetyltransferase activity
S-malonyltransferase activity
3-hydroxyoctanoyl- dehydratase activity
3-hydroxypalmitoyl- dehydratase activity
3-oxoacyl- reductase (NADPH) activity
3-oxoacyl- synthase activity
drug binding
enoyl- reductase (NADPH, A-specific) activity
enoyl- reductase (NADPH, B-specific) activity
fatty acid synthase activity
myristoyl- hydrolase activity
NADPH binding
oleoyl- hydrolase activity
palmitoyl- hydrolase activity
poly(A) RNA binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome
glycogen granule
Golgi apparatus
melanosome
membrane
mitochondrion
plasma membrane - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Fatty acid biosynthesis
Fatty acid metabolism
Hydrolase
Lipid biosynthesis
Lipid metabolism
Lyase
Multifunctional enzyme
NAD
NADP
Oxidoreductase
Phosphopantetheine
Phosphoprotein
Polymorphism
Pyridoxal phosphate
Reference proteome
Transferase - Interacts With:
- Q99IB8