Names & Taxonomy

Uniprot ID:
P49286
Entry Name:
MTR1B_HUMAN
Status:
reviewed
Protein Names:
Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor)
Gene Names:
MTNR1B
Gene Names Primary:
MTNR1B
Organism:
Homo sapiens (Human)

Structure

Length:
362
Sequence:
MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Function

Function:
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Cross Reference Drug Bank:
DB06594 DB01065 DB00980 DB09071
Gene Ontology Go:
cytosol
integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
melatonin receptor activity
camera-type eye development
cell surface receptor signaling pathway
circadian rhythm
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
glucose homeostasis
negative regulation of cGMP metabolic process
negative regulation of cytosolic calcium ion concentration
negative regulation of delayed rectifier potassium channel activity
negative regulation of insulin secretion
negative regulation of neuron apoptotic process
negative regulation of transmission of nerve impulse
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of transmission of nerve impulse
positive regulation of vasodilation
regulation of insulin secretion
regulation of neuronal action potential
synaptic transmission
Gene Ontology Biological Process:
camera-type eye development
cell surface receptor signaling pathway
circadian rhythm
glucose homeostasis
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cGMP metabolic process
negative regulation of cytosolic calcium ion concentration
negative regulation of delayed rectifier potassium channel activity
negative regulation of insulin secretion
negative regulation of neuron apoptotic process
negative regulation of transmission of nerve impulse
positive regulation of circadian sleep/wake cycle, non-REM sleep
positive regulation of transmission of nerve impulse
positive regulation of vasodilation
regulation of insulin secretion
regulation of neuronal action potential
synaptic transmission
Gene Ontology Molecular Function:
G-protein coupled receptor activity
melatonin receptor activity
Gene Ontology Cellular Component:
cytosol
integral component of plasma membrane
plasma membrane
Keywords:
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix
Interacts With:
P48039; O76081; Q14669

Publication

PubMed ID:
7568007 10696804 15489334