Names & Taxonomy
- Uniprot ID:
- P49257
- Entry Name:
- LMAN1_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein ERGIC-53 (ER-Golgi intermediate compartment 53 kDa protein) (Gp58) (Intracellular mannose-specific lectin MR60) (Lectin mannose-binding 1)
- Gene Names:
- LMAN1 ERGIC53 F5F8D
- Gene Names Primary:
- LMAN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 510
- Sequence:
- MAGSRQRGLRARVRPLFCALLLSLGRFVRGDGVGGDPAVALPHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLTEPGKEPPTPDKEISEKEKEKYQEEFEHFQQELDKKKEEFQKGHPDLQGQPAEEIFESVGDRELRQVFEGQNRIHLEIKQLNRQLDMILDEQRRYVSSLTEEISKRGAGMPGQHGQITQQELDTVVKTQHEILRQVNEMKNSMSETVRLVSGMQHPGSAGGVYETTQHFIDIKEHLHIVKRDIDNLVQRNMPSNEKPKCPELPPFPSCLSTVHFIIFVVVQTVLFIGYIMYRSQQEAAAKKFF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Function
- Function:
- Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
- Cross Reference Drug Bank:
- DB00025
- Gene Ontology Go:
- endoplasmic reticulum membrane
endoplasmic reticulum-Golgi intermediate compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
ER to Golgi transport vesicle membrane
extracellular exosome
Golgi membrane
host cell perinuclear region of cytoplasm
integral component of membrane
membrane
sarcomere
mannose binding
metal ion binding
unfolded protein binding
blood coagulation
cellular protein metabolic process
COPII vesicle coating
endoplasmic reticulum organization
ER to Golgi vesicle-mediated transport
Golgi organization
membrane organization
positive regulation of organelle organization
post-translational protein modification
protein folding
protein N-linked glycosylation via asparagine
protein transport - Gene Ontology Biological Process:
- blood coagulation
cellular protein metabolic process
COPII vesicle coating
endoplasmic reticulum organization
ER to Golgi vesicle-mediated transport
Golgi organization
membrane organization
positive regulation of organelle organization
post-translational protein modification
protein folding
protein N-linked glycosylation via asparagine
protein transport - Gene Ontology Molecular Function:
- mannose binding
metal ion binding
unfolded protein binding - Gene Ontology Cellular Component:
- endoplasmic reticulum-Golgi intermediate compartment
endoplasmic reticulum-Golgi intermediate compartment membrane
endoplasmic reticulum membrane
ER to Golgi transport vesicle membrane
extracellular exosome
Golgi membrane
host cell perinuclear region of cytoplasm
integral component of membrane
membrane
sarcomere - Keywords:
- 3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
ER-Golgi transport
Endoplasmic reticulum
Golgi apparatus
Lectin
Membrane
Metal-binding
Phosphoprotein
Polymorphism
Protein transport
Reference proteome
Signal
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q9BS26; O15260