Names & Taxonomy
- Uniprot ID:
- P49190
- Entry Name:
- PTH2R_HUMAN
- Status:
- reviewed
- Protein Names:
- Parathyroid hormone 2 receptor (PTH2 receptor)
- Gene Names:
- PTH2R PTHR2
- Gene Names Primary:
- PTH2R
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 550
- Sequence:
- MAGLGASLHVWGWLMLGSCLLARAQLDSDGTITIEEQIVLVLKAKVQCELNITAQLQEGEGNCFPEWDGLICWPRGTVGKISAVPCPPYIYDFNHKGVAFRHCNPNGTWDFMHSLNKTWANYSDCLRFLQPDISIGKQEFFERLYVMYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIHMHLFVSFMLRATSIFVKDRVVHAHIGVKELESLIMQDDPQNSIEATSVDKSQYIGCKIAVVMFIYFLATNYYWILVEGLYLHNLIFVAFFSDTKYLWGFILIGWGFPAAFVAAWAVARATLADARCWELSAGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDTRKQYRKLAKSTLVLVLVFGVHYIVFVCLPHSFTGLGWEIRMHCELFFNSFQGFFVSIIYCYCNGEVQAEVKKMWSRWNLSVDWKRTPPCGSRRCGSVLTTVTHSTSSQSQVAASTRMVLISGKAAKIASRQPDSHITLPGYVWSNSEQDCLPHSFHEETKEDSGRQGDDILMEKPSRPMESNPDTEGCQGETEDVL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).
- Cross Reference Drug Bank:
- DB05829
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
parathyroid hormone receptor activity
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway - Gene Ontology Biological Process:
- cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway - Gene Ontology Molecular Function:
- parathyroid hormone receptor activity
- Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- Q9NP66