Names & Taxonomy

Uniprot ID:
P48775
Entry Name:
T23O_HUMAN
Status:
reviewed
Protein Names:
Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)
Gene Names:
TDO2 TDO
Gene Names Primary:
TDO2
Organism:
Homo sapiens (Human)

Structure

Length:
406
Sequence:
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
Proteomes:
UP000005640

Function

Function:
Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).
Pathway:
Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Catalytic Activity:
L-tryptophan + O(2) = N-formyl-L-kynurenine.
Cofactor:
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
Cross Reference Drug Bank:
DB00150 DB00779 DB00500
Gene Ontology Go:
cytosol
amino acid binding
heme binding
metal ion binding
oxygen binding
tryptophan 2,3-dioxygenase activity
cellular nitrogen compound metabolic process
small molecule metabolic process
tryptophan catabolic process
tryptophan catabolic process to acetyl-CoA
tryptophan catabolic process to kynurenine
Gene Ontology Biological Process:
cellular nitrogen compound metabolic process
small molecule metabolic process
tryptophan catabolic process
tryptophan catabolic process to acetyl-CoA
tryptophan catabolic process to kynurenine
Gene Ontology Molecular Function:
amino acid binding
heme binding
metal ion binding
oxygen binding
tryptophan 2,3-dioxygenase activity
Gene Ontology Cellular Component:
cytosol
Keywords:
3D-structure
Coiled coil
Complete proteome
Dioxygenase
Heme
Iron
Metal-binding
Oxidoreductase
Reference proteome
Tryptophan catabolism
Interacts With:
O95671; O60762; P06730; Q9H8S9; Q70IA8; Q9NPG2; O00560; Q9H190; Q96H43

Publication

PubMed ID:
8666386 14702039 15489334