Names & Taxonomy
- Uniprot ID:
- P48775
- Entry Name:
- T23O_HUMAN
- Status:
- reviewed
- Protein Names:
- Tryptophan 2,3-dioxygenase (TDO) (EC 1.13.11.11) (Tryptamin 2,3-dioxygenase) (Tryptophan oxygenase) (TO) (TRPO) (Tryptophan pyrrolase) (Tryptophanase)
- Gene Names:
- TDO2 TDO
- Gene Names Primary:
- TDO2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 406
- Sequence:
- MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
- Proteomes:
- UP000005640
Function
- Function:
- Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity).
- Pathway:
- Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
- Catalytic Activity:
- L-tryptophan + O(2) = N-formyl-L-kynurenine.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB00150 DB00779 DB00500
- Gene Ontology Go:
- cytosol
amino acid binding
heme binding
metal ion binding
oxygen binding
tryptophan 2,3-dioxygenase activity
cellular nitrogen compound metabolic process
small molecule metabolic process
tryptophan catabolic process
tryptophan catabolic process to acetyl-CoA
tryptophan catabolic process to kynurenine - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
small molecule metabolic process
tryptophan catabolic process
tryptophan catabolic process to acetyl-CoA
tryptophan catabolic process to kynurenine - Gene Ontology Molecular Function:
- amino acid binding
heme binding
metal ion binding
oxygen binding
tryptophan 2,3-dioxygenase activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Coiled coil
Complete proteome
Dioxygenase
Heme
Iron
Metal-binding
Oxidoreductase
Reference proteome
Tryptophan catabolism - Interacts With:
- O95671; O60762; P06730; Q9H8S9; Q70IA8; Q9NPG2; O00560; Q9H190; Q96H43