Names & Taxonomy

Uniprot ID:
P48764
Entry Name:
SL9A3_HUMAN
Status:
reviewed
Protein Names:
Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3)
Gene Names:
SLC9A3 NHE3
Gene Names Primary:
SLC9A3
Organism:
Homo sapiens (Human)

Structure

Length:
834
Sequence:
MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKRLESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGETVVPSQRARTQIPYSPGTFCRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Apical cell membrane
Intramembrane:
INTRAMEM 13 24 Name=A/M1.

Function

Function:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Gene Ontology Go:
apical plasma membrane
brush border
brush border membrane
cell surface
extracellular exosome
integral component of membrane
plasma membrane
PDZ domain binding
sodium:proton antiporter activity
circadian rhythm
ion transport
receptor-mediated endocytosis
regulation of pH
regulation of sodium ion transport
response to glucocorticoid
transmembrane transport
Gene Ontology Biological Process:
circadian rhythm
ion transport
receptor-mediated endocytosis
regulation of pH
regulation of sodium ion transport
response to glucocorticoid
transmembrane transport
Gene Ontology Molecular Function:
PDZ domain binding
sodium:proton antiporter activity
Gene Ontology Cellular Component:
apical plasma membrane
brush border
brush border membrane
cell surface
extracellular exosome
integral component of membrane
plasma membrane
Keywords:
Alternative splicing
Antiport
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q6P0Q8

Publication

PubMed ID:
7631746 15372022 15489334 19088451 18829453 20584908