Names & Taxonomy
- Uniprot ID:
- P48764
- Entry Name:
- SL9A3_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3)
- Gene Names:
- SLC9A3 NHE3
- Gene Names Primary:
- SLC9A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 834
- Sequence:
- MWGLGARGPDRGLLLALALGGLARAGGVEVEPGGAHGESGGFQVVTFEWAHVQDPYVIALWILVASLAKIGFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTVFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVVGTVWNAATTGLSLYGVFLSGLMGDLQIGLLDFLLFGSLMAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVALGGDNVTGVDCVKGIVSFFVVSLGGTLVGVVFAFLLSLVTRFTKHVRIIEPGFVFIISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASSAETIIFMFLGISAVNPFIWTWNTAFVLLTLVFISVYRAIGVVLQTWLLNRYRMVQLEPIDQVVLSYGGLRGAVAFALVVLLDGDKVKEKNLFVSTTIIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPRLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSHFDRKFLSRVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNVVNVDFTPRSSTVEASVSYLLRENVSAVCLDMQSLEQRRRSIRDAEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPTEDEKQDREIFHRTMRKRLESFKSTKLGLNQNKKAAKLYKRERAQKRRNSSIPNGKLPMESPAQNFTIKEKDLELSDTEEPPNYDEEMSGGIEFLASVTKDTASDSPAGIDNPVFSPDEALDRSLLARLPPWLSPGETVVPSQRARTQIPYSPGTFCRLMPFRLSSKSVDSFLQADGPEERPPAALPESTHM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Apical cell membrane
- Intramembrane:
- INTRAMEM 13 24 Name=A/M1.
Function
- Function:
- Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
- Gene Ontology Go:
- apical plasma membrane
brush border
brush border membrane
cell surface
extracellular exosome
integral component of membrane
plasma membrane
PDZ domain binding
sodium:proton antiporter activity
circadian rhythm
ion transport
receptor-mediated endocytosis
regulation of pH
regulation of sodium ion transport
response to glucocorticoid
transmembrane transport - Gene Ontology Biological Process:
- circadian rhythm
ion transport
receptor-mediated endocytosis
regulation of pH
regulation of sodium ion transport
response to glucocorticoid
transmembrane transport - Gene Ontology Molecular Function:
- PDZ domain binding
sodium:proton antiporter activity - Gene Ontology Cellular Component:
- apical plasma membrane
brush border
brush border membrane
cell surface
extracellular exosome
integral component of membrane
plasma membrane - Keywords:
- Alternative splicing
Antiport
Cell membrane
Complete proteome
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Sodium
Sodium transport
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q6P0Q8