Names & Taxonomy
- Uniprot ID:
- P48664
- Entry Name:
- EAA4_HUMAN
- Status:
- reviewed
- Protein Names:
- Excitatory amino acid transporter 4 (Sodium-dependent glutamate/aspartate transporter) (Solute carrier family 1 member 6)
- Gene Names:
- SLC1A6 EAAT4
- Gene Names Primary:
- SLC1A6
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 564
- Sequence:
- MSSHGNSLFLRESGQRLGRVGWLQRLQESLQQRALRTRLRLQTMTLEHVLRFLRRNAFILLTVSAVVIGVSLAFALRPYQLTYRQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLDNKATGRMGMRAAVYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETIPTADAFMDLIRNMFPPNLVEACFKQFKTQYSTRVVTRTMVRTENGSEPGASMPPPFSVENGTSFLENVTRALGTLQEMLSFEETVPVPGSANGINALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHLSQRELELQEAELTLPSLGKPYKSLMAQEKGASRGRGGNESAM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Transports L-glutamate and also L- and D-aspartate. Seems to act as a symport by cotransporting sodium.
- Gene Ontology Go:
- Golgi apparatus
integral component of plasma membrane
membrane
plasma membrane
presynapse
L-aspartate transmembrane transporter activity
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity
aspartate transport
glutamate secretion
ion transport
L-aspartate transmembrane transport
L-glutamate transport
neurotransmitter secretion
regulation of membrane potential
synaptic transmission
transmembrane transport - Gene Ontology Biological Process:
- aspartate transport
glutamate secretion
ion transport
L-aspartate transmembrane transport
L-glutamate transport
neurotransmitter secretion
regulation of membrane potential
synaptic transmission
transmembrane transport - Gene Ontology Molecular Function:
- L-aspartate transmembrane transporter activity
L-glutamate transmembrane transporter activity
sodium:dicarboxylate symporter activity - Gene Ontology Cellular Component:
- Golgi apparatus
integral component of plasma membrane
membrane
plasma membrane
presynapse - Keywords:
- Alternative splicing
Complete proteome
Glycoprotein
Membrane
Phosphoprotein
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport