Names & Taxonomy

Uniprot ID:
P48637
Entry Name:
GSHB_HUMAN
Status:
reviewed
Protein Names:
Glutathione synthetase (GSH synthetase) (GSH-S) (EC 6.3.2.3) (Glutathione synthase)
Gene Names:
GSS
Gene Names Primary:
GSS
Organism:
Homo sapiens (Human)

Structure

Length:
474
Sequence:
MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDAVSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEGIAQTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGGLASRTPAVHRHVLSVLSKTKEAGKILSNNPSKGLALGIAKAWELYGSPNALVLLIAQEKERNIFDQRAIENELLARNIHVIRRTFEDISEKGSLDQDRRLFVDGQEIAVVYFRDGYMPRQYSLQNWEARLLLERSHAAKCPDIATQLAGTKKVQQELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDVGEEGDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQLKDSEERASYILMEKIEPEPFENCLLRPGSPARVVQCISELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV
Proteomes:
UP000005640

Function

Pathway:
Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.
Catalytic Activity:
ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Cross Reference Drug Bank:
DB06151 DB00143 DB00145 DB00151
Gene Ontology Go:
cytosol
extracellular exosome
ATP binding
glutathione binding
glutathione synthase activity
glycine binding
magnesium ion binding
protein homodimerization activity
aging
cellular amino acid metabolic process
glutathione biosynthetic process
glutathione derivative biosynthetic process
nervous system development
response to amino acid
response to cadmium ion
response to nutrient levels
response to oxidative stress
response to tumor necrosis factor
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
aging
cellular amino acid metabolic process
glutathione biosynthetic process
glutathione derivative biosynthetic process
nervous system development
response to amino acid
response to cadmium ion
response to nutrient levels
response to oxidative stress
response to tumor necrosis factor
small molecule metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
ATP binding
glutathione binding
glutathione synthase activity
glycine binding
magnesium ion binding
protein homodimerization activity
Gene Ontology Cellular Component:
cytosol
extracellular exosome
Keywords:
3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Disease mutation
Glutathione biosynthesis
Hereditary hemolytic anemia
Ligase
Magnesium
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Interacts With:
P54274

Publication

PubMed ID:
7646467 19672693 14702039 11780052 15489334 19413330 21269460 22223895 24275569 10369661 8896573 9215686