Names & Taxonomy
- Uniprot ID:
- P48551
- Entry Name:
- INAR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)
- Gene Names:
- IFNAR2 IFNABR IFNARB
- Gene Names Primary:
- IFNAR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 515
- Sequence:
- MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMDMVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLIDPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGRITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPTFPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane
Function
- Function:
- Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).
- Cross Reference Drug Bank:
- DB00011 DB00018 DB00069 DB00060 DB00068 DB00008 DB00022
- Gene Ontology Go:
- extracellular region
extracellular space
integral component of plasma membrane
intracellular
plasma membrane
interleukin-20 binding
protein kinase binding
type I interferon binding
type I interferon receptor activity
cell proliferation
cell surface receptor signaling pathway
cytokine-mediated signaling pathway
JAK-STAT cascade
regulation of transcription from RNA polymerase II promoter
regulation of type I interferon-mediated signaling pathway
response to interferon-alpha
response to virus
type I interferon signaling pathway - Gene Ontology Biological Process:
- cell proliferation
cell surface receptor signaling pathway
cytokine-mediated signaling pathway
JAK-STAT cascade
regulation of transcription from RNA polymerase II promoter
regulation of type I interferon-mediated signaling pathway
response to interferon-alpha
response to virus
type I interferon signaling pathway - Gene Ontology Molecular Function:
- interleukin-20 binding
protein kinase binding
type I interferon binding
type I interferon receptor activity - Gene Ontology Cellular Component:
- extracellular region
extracellular space
integral component of plasma membrane
intracellular
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix - Interacts With:
- Q92793; P63244; Q00978; P23458; P42224; P52630; Q9UMW8