Names & Taxonomy

Uniprot ID:
P48551
Entry Name:
INAR2_HUMAN
Status:
reviewed
Protein Names:
Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)
Gene Names:
IFNAR2 IFNABR IFNARB
Gene Names Primary:
IFNAR2
Organism:
Homo sapiens (Human)

Structure

Length:
515
Sequence:
MLLSQNAFIFRSLNLVLMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAKIGGIITVFLIALVLTSTIVTLKWIGYICLRNSLPKVLNFHNFLAWPFPNLPPLEAMDMVEVIYINRKKKVWDYNYDDESDSDTEAAPRTSGGGYTMHGLTVRPLGQASATSTESQLIDPESEEEPDLPEVDVELPTMPKDSPQQLELLSGPCERRKSPLQDPFPEEDYSSTEGSGGRITFNVDLNSVFLRVLDDEDSDDLEAPLMLSSHLEEMVDPEDPDNVQSNHLLASGEGTQPTFPSPSSEGLWSEDAPSDQSDTSESDVDLGDGYIMR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Cell membrane

Function

Function:
Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity (PubMed:7759950).
Cross Reference Drug Bank:
DB00011 DB00018 DB00069 DB00060 DB00068 DB00008 DB00022
Gene Ontology Go:
extracellular region
extracellular space
integral component of plasma membrane
intracellular
plasma membrane
interleukin-20 binding
protein kinase binding
type I interferon binding
type I interferon receptor activity
cell proliferation
cell surface receptor signaling pathway
cytokine-mediated signaling pathway
JAK-STAT cascade
regulation of transcription from RNA polymerase II promoter
regulation of type I interferon-mediated signaling pathway
response to interferon-alpha
response to virus
type I interferon signaling pathway
Gene Ontology Biological Process:
cell proliferation
cell surface receptor signaling pathway
cytokine-mediated signaling pathway
JAK-STAT cascade
regulation of transcription from RNA polymerase II promoter
regulation of type I interferon-mediated signaling pathway
response to interferon-alpha
response to virus
type I interferon signaling pathway
Gene Ontology Molecular Function:
interleukin-20 binding
protein kinase binding
type I interferon binding
type I interferon receptor activity
Gene Ontology Cellular Component:
extracellular region
extracellular space
integral component of plasma membrane
intracellular
plasma membrane
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix
Interacts With:
Q92793; P63244; Q00978; P23458; P42224; P52630; Q9UMW8

Publication

PubMed ID:
8181059 7588638 7665574 7759950 14702039 10830953 9121453 10049744 11682488 12105218 12842042 16757563 24075985 17001036 20496919 21854986 21819146