Names & Taxonomy
- Uniprot ID:
- P48506
- Entry Name:
- GSH1_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase)
- Gene Names:
- GCLC GLCL GLCLC
- Gene Names Primary:
- GCLC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 637
- Sequence:
- MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENKKVRLVLSGEKVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEANMRKRRKEATSILEENQALCTITSFPRLGCPGFTLPEVKPNPVEGGASKSLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFTEDDEASRASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSKCGEKYNDIDLTIDKEIYEQLLQEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVLQGMFYFRKDICKGGNAVVDGCGKAQNSTELAAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYSLILKCNQIANELCECPELLGSAFRKVKYSGSKTDSSN
- Proteomes:
- UP000005640
Function
- Pathway:
- Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.
- Catalytic Activity:
- ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.
- Enzyme Regulation:
- ENZYME REGULATION: Feedback inhibition by glutathione.
- Cross Reference Drug Bank:
- DB00151 DB00163
- Gene Ontology Go:
- cytosol
glutamate-cysteine ligase complex
ADP binding
ATP binding
coenzyme binding
glutamate binding
glutamate-cysteine ligase activity
magnesium ion binding
apoptotic mitochondrial changes
cell redox homeostasis
cellular nitrogen compound metabolic process
cysteine metabolic process
glutamate metabolic process
glutathione biosynthetic process
glutathione derivative biosynthetic process
L-ascorbic acid metabolic process
negative regulation of apoptotic process
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of neuron apoptotic process
negative regulation of protein ubiquitination
negative regulation of transcription, DNA-templated
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of blood vessel size
regulation of mitochondrial depolarization
response to arsenic-containing substance
response to heat
response to hormone
response to nitrosative stress
response to oxidative stress
small molecule metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- apoptotic mitochondrial changes
cell redox homeostasis
cellular nitrogen compound metabolic process
cysteine metabolic process
glutamate metabolic process
glutathione biosynthetic process
glutathione derivative biosynthetic process
L-ascorbic acid metabolic process
negative regulation of apoptotic process
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of neuron apoptotic process
negative regulation of protein ubiquitination
negative regulation of transcription, DNA-templated
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of blood vessel size
regulation of mitochondrial depolarization
response to arsenic-containing substance
response to heat
response to hormone
response to nitrosative stress
response to oxidative stress
small molecule metabolic process
sulfur amino acid metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- ADP binding
ATP binding
coenzyme binding
glutamate binding
glutamate-cysteine ligase activity
magnesium ion binding - Gene Ontology Cellular Component:
- cytosol
glutamate-cysteine ligase complex - Keywords:
- ATP-binding
Acetylation
Complete proteome
Disease mutation
Glutathione biosynthesis
Hereditary hemolytic anemia
Ligase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome