Names & Taxonomy

Uniprot ID:
P48443
Entry Name:
RXRG_HUMAN
Status:
reviewed
Protein Names:
Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma)
Gene Names:
RXRG NR2B3
Gene Names Primary:
RXRG
Organism:
Homo sapiens (Human)

Structure

Length:
463
Sequence:
MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus

Function

Function:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
Cross Reference Drug Bank:
DB00459 DB00210 DB00523 DB00307 DB00755
Gene Ontology Go:
nucleoplasm
9-cis retinoic acid receptor activity
RNA polymerase II regulatory region sequence-specific DNA binding
steroid hormone receptor activity
zinc ion binding
gene expression
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
protein homotetramerization
transcription initiation from RNA polymerase II promoter
Gene Ontology Biological Process:
gene expression
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
protein homotetramerization
transcription initiation from RNA polymerase II promoter
Gene Ontology Molecular Function:
9-cis retinoic acid receptor activity
RNA polymerase II regulatory region sequence-specific DNA binding
steroid hormone receptor activity
zinc ion binding
Gene Ontology Cellular Component:
nucleoplasm
Keywords:
3D-structure
Complete proteome
DNA-binding
Metal-binding
Nucleus
Receptor
Reference proteome
Transcription
Transcription regulation
Zinc
Zinc-finger
Interacts With:
Q15777; F1D8P7; Q13133; P10276; P10276-2; P10826-2

Publication

PubMed ID:
16710414 15489334