Names & Taxonomy
- Uniprot ID:
- P48443
- Entry Name:
- RXRG_HUMAN
- Status:
- reviewed
- Protein Names:
- Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma)
- Gene Names:
- RXRG NR2B3
- Gene Names Primary:
- RXRG
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 463
- Sequence:
- MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
- Cross Reference Drug Bank:
- DB00459 DB00210 DB00523 DB00307 DB00755
- Gene Ontology Go:
- nucleoplasm
9-cis retinoic acid receptor activity
RNA polymerase II regulatory region sequence-specific DNA binding
steroid hormone receptor activity
zinc ion binding
gene expression
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
protein homotetramerization
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- gene expression
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
protein homotetramerization
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- 9-cis retinoic acid receptor activity
RNA polymerase II regulatory region sequence-specific DNA binding
steroid hormone receptor activity
zinc ion binding - Gene Ontology Cellular Component:
- nucleoplasm
- Keywords:
- 3D-structure
Complete proteome
DNA-binding
Metal-binding
Nucleus
Receptor
Reference proteome
Transcription
Transcription regulation
Zinc
Zinc-finger - Interacts With:
- Q15777; F1D8P7; Q13133; P10276; P10276-2; P10826-2