Names & Taxonomy

Uniprot ID:
P48357
Entry Name:
LEPR_HUMAN
Status:
reviewed
Protein Names:
Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295)
Gene Names:
LEPR DB OBR
Gene Names Primary:
LEPR
Organism:
Homo sapiens (Human)

Structure

Length:
1165
Sequence:
MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFNSVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSWEIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKTFASYMPQFQTCSTQTHKIMENKMCDLTV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).
Cross Reference Drug Bank:
DB09046
Gene Ontology Go:
basolateral plasma membrane
extracellular region
integral component of membrane
plasma membrane
receptor complex
identical protein binding
leptin receptor activity
transmembrane signaling receptor activity
angiogenesis
bone growth
cell surface receptor signaling pathway
cholesterol metabolic process
energy homeostasis
energy reserve metabolic process
glucose homeostasis
leptin-mediated signaling pathway
multicellular organism development
negative regulation of autophagy
negative regulation of gluconeogenesis
negative regulation of hydrolase activity
regulation of bone remodeling
regulation of energy homeostasis
regulation of feeding behavior
response to leptin
sexual reproduction
T cell differentiation
Gene Ontology Biological Process:
angiogenesis
bone growth
cell surface receptor signaling pathway
cholesterol metabolic process
energy homeostasis
energy reserve metabolic process
glucose homeostasis
leptin-mediated signaling pathway
multicellular organism development
negative regulation of autophagy
negative regulation of gluconeogenesis
negative regulation of hydrolase activity
regulation of bone remodeling
regulation of energy homeostasis
regulation of feeding behavior
response to leptin
sexual reproduction
T cell differentiation
Gene Ontology Molecular Function:
identical protein binding
leptin receptor activity
transmembrane signaling receptor activity
Gene Ontology Cellular Component:
basolateral plasma membrane
extracellular region
integral component of membrane
plasma membrane
receptor complex
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Obesity
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane
Transmembrane helix
Interacts With:
P62993; P0CG48

Publication

PubMed ID:
8548812 8805376 8616721 9158141 9061609 9537324 9929394 9600917 9786864 10896907 12504075 16052473 16335952 19159218 25232147 24275569 25060689 22405007 8666155 9144432 9287054 9175732 9860295 18987736 25751111