Names & Taxonomy
- Uniprot ID:
- P48163
- Entry Name:
- MAOX_HUMAN
- Status:
- reviewed
- Protein Names:
- NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1)
- Gene Names:
- ME1
- Gene Names Primary:
- ME1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 572
- Sequence:
- MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWPEEVQKIQTKVDQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Catalytic Activity:
- (S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.; Oxaloacetate = pyruvate + CO(2).
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 102 102 Proton donor.
- Gene Ontology Go:
- cytosol
mitochondrion
ADP binding
electron carrier activity
malate dehydrogenase (decarboxylating) (NAD+) activity
malate dehydrogenase (decarboxylating) (NADP+) activity
malic enzyme activity
manganese ion binding
NAD binding
NADP binding
oxaloacetate decarboxylase activity
carbohydrate metabolic process
cellular lipid metabolic process
malate metabolic process
NADP biosynthetic process
protein tetramerization
regulation of NADP metabolic process
response to carbohydrate
response to hormone
small molecule metabolic process - Gene Ontology Biological Process:
- carbohydrate metabolic process
cellular lipid metabolic process
malate metabolic process
NADP biosynthetic process
protein tetramerization
regulation of NADP metabolic process
response to carbohydrate
response to hormone
small molecule metabolic process - Gene Ontology Molecular Function:
- ADP binding
electron carrier activity
malate dehydrogenase (decarboxylating) (NAD+) activity
malate dehydrogenase (decarboxylating) (NADP+) activity
malic enzyme activity
manganese ion binding
NAD binding
NADP binding
oxaloacetate decarboxylase activity - Gene Ontology Cellular Component:
- cytosol
mitochondrion - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Metal-binding
NADP
Oxidoreductase
Phosphoprotein
Reference proteome