Names & Taxonomy

Uniprot ID:
P48163
Entry Name:
MAOX_HUMAN
Status:
reviewed
Protein Names:
NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1)
Gene Names:
ME1
Gene Names Primary:
ME1
Organism:
Homo sapiens (Human)

Structure

Length:
572
Sequence:
MEPEAPRRRHTHQRGYLLTRNPHLNKDLAFTLEERQQLNIHGLLPPSFNSQEIQVLRVVKNFEHLNSDFDRYLLLMDLQDRNEKLFYRVLTSDIEKFMPIVYTPTVGLACQQYSLVFRKPRGLFITIHDRGHIASVLNAWPEDVIKAIVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGMNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGSEYDDFLDEFMEAVSSKYGMNCLIQFEDFANVNAFRLLNKYRNQYCTFNDDIQGTASVAVAGLLAALRITKNKLSDQTILFQGAGEAALGIAHLIVMALEKEGLPKEKAIKKIWLVDSKGLIVKGRASLTQEKEKFAHEHEEMKNLEAIVQEIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECSAEQCYKITKGRAIFASGSPFDPVTLPNGQTLYPGQGNNSYVFPGVALGVVACGLRQITDNIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVKDAYQEKTATVYPEPQNKEAFVRSQMYSTDYDQILPDCYSWPEEVQKIQTKVDQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Catalytic Activity:
(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH.; Oxaloacetate = pyruvate + CO(2).
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Active Site:
ACT_SITE 102 102 Proton donor.
Gene Ontology Go:
cytosol
mitochondrion
ADP binding
electron carrier activity
malate dehydrogenase (decarboxylating) (NAD+) activity
malate dehydrogenase (decarboxylating) (NADP+) activity
malic enzyme activity
manganese ion binding
NAD binding
NADP binding
oxaloacetate decarboxylase activity
carbohydrate metabolic process
cellular lipid metabolic process
malate metabolic process
NADP biosynthetic process
protein tetramerization
regulation of NADP metabolic process
response to carbohydrate
response to hormone
small molecule metabolic process
Gene Ontology Biological Process:
carbohydrate metabolic process
cellular lipid metabolic process
malate metabolic process
NADP biosynthetic process
protein tetramerization
regulation of NADP metabolic process
response to carbohydrate
response to hormone
small molecule metabolic process
Gene Ontology Molecular Function:
ADP binding
electron carrier activity
malate dehydrogenase (decarboxylating) (NAD+) activity
malate dehydrogenase (decarboxylating) (NADP+) activity
malic enzyme activity
manganese ion binding
NAD binding
NADP binding
oxaloacetate decarboxylase activity
Gene Ontology Cellular Component:
cytosol
mitochondrion
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Metal-binding
NADP
Oxidoreductase
Phosphoprotein
Reference proteome

Publication

PubMed ID:
8187880 7622060 14702039 14574404 15489334 8804575 19413330 21269460