Names & Taxonomy
- Uniprot ID:
- P48147
- Entry Name:
- PPCE_HUMAN
- Status:
- reviewed
- Protein Names:
- Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme)
- Gene Names:
- PREP PEP
- Gene Names Primary:
- PREP
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 710
- Sequence:
- MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
- Catalytic Activity:
- Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.
- Active Site:
- ACT_SITE 554 554 Charge relay system.
- Cross Reference Drug Bank:
- DB00107
- Gene Ontology Go:
- cytoplasm
membrane
nucleus
serine-type endopeptidase activity
serine-type exopeptidase activity
serine-type peptidase activity
proteolysis - Gene Ontology Biological Process:
- proteolysis
- Gene Ontology Molecular Function:
- serine-type endopeptidase activity
serine-type exopeptidase activity
serine-type peptidase activity - Gene Ontology Cellular Component:
- cytoplasm
membrane
nucleus - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Polymorphism
Protease
Reference proteome
Serine protease - Interacts With:
- P04406