Names & Taxonomy

Uniprot ID:
P48147
Entry Name:
PPCE_HUMAN
Status:
reviewed
Protein Names:
Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme)
Gene Names:
PREP PEP
Gene Names Primary:
PREP
Organism:
Homo sapiens (Human)

Structure

Length:
710
Sequence:
MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIRGLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILSDDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTHDGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAELSDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVFTFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNILQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPRVFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISITPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKEGYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYGCSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIVGRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm.

Function

Function:
Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long.
Catalytic Activity:
Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.
Active Site:
ACT_SITE 554 554 Charge relay system.
Cross Reference Drug Bank:
DB00107
Gene Ontology Go:
cytoplasm
membrane
nucleus
serine-type endopeptidase activity
serine-type exopeptidase activity
serine-type peptidase activity
proteolysis
Gene Ontology Biological Process:
proteolysis
Gene Ontology Molecular Function:
serine-type endopeptidase activity
serine-type exopeptidase activity
serine-type peptidase activity
Gene Ontology Cellular Component:
cytoplasm
membrane
nucleus
Keywords:
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Hydrolase
Polymorphism
Protease
Reference proteome
Serine protease
Interacts With:
P04406

Publication

PubMed ID:
7959018 8089089 14574404 15489334 7588785 19608861 21269460 22814378 18606544