Names & Taxonomy
- Uniprot ID:
- P48067
- Entry Name:
- SC6A9_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9)
- Gene Names:
- SLC6A9
- Gene Names Primary:
- SLC6A9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 706
- Sequence:
- MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
Function
- Function:
- Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
- Cross Reference Drug Bank:
- DB00145
- Gene Ontology Go:
- integral component of plasma membrane
membrane
plasma membrane
presynapse
glycine:sodium symporter activity
neurotransmitter:sodium symporter activity
glycine import
glycine secretion, neurotransmission
synaptic transmission, glycinergic
transmembrane transport
transport - Gene Ontology Biological Process:
- glycine import
glycine secretion, neurotransmission
synaptic transmission, glycinergic
transmembrane transport
transport - Gene Ontology Molecular Function:
- glycine:sodium symporter activity
neurotransmitter:sodium symporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
membrane
plasma membrane
presynapse - Keywords:
- Alternative splicing
Amino-acid transport
Complete proteome
Membrane
Neurotransmitter transport
Phosphoprotein
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport