Names & Taxonomy

Uniprot ID:
P48065
Entry Name:
S6A12_HUMAN
Status:
reviewed
Protein Names:
Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12)
Gene Names:
SLC6A12
Gene Names Primary:
SLC6A12
Organism:
Homo sapiens (Human)

Structure

Length:
614
Sequence:
MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSPTREGLIAGEKETHL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation.
Gene Ontology Go:
integral component of membrane
integral component of plasma membrane
neuron projection
plasma membrane
presynapse
gamma-aminobutyric acid:sodium symporter activity
neurotransmitter:sodium symporter activity
amino acid transport
cellular hyperosmotic response
cellular water homeostasis
gamma-aminobutyric acid transport
ion transport
neurotransmitter secretion
neurotransmitter transport
response to organic substance
synaptic transmission
transmembrane transport
transport
Gene Ontology Biological Process:
amino acid transport
cellular hyperosmotic response
cellular water homeostasis
gamma-aminobutyric acid transport
ion transport
neurotransmitter secretion
neurotransmitter transport
response to organic substance
synaptic transmission
transmembrane transport
transport
Gene Ontology Molecular Function:
gamma-aminobutyric acid:sodium symporter activity
neurotransmitter:sodium symporter activity
Gene Ontology Cellular Component:
integral component of membrane
integral component of plasma membrane
neuron projection
plasma membrane
presynapse
Keywords:
Complete proteome
Disulfide bond
Glycoprotein
Membrane
Neurotransmitter transport
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q04864

Publication

PubMed ID:
7589472 7861179 14702039 16541075 15489334