Names & Taxonomy

Uniprot ID:
P48048
Entry Name:
KCNJ1_HUMAN
Status:
reviewed
Protein Names:
ATP-sensitive inward rectifier potassium channel 1 (ATP-regulated potassium channel ROM-K) (Inward rectifier K(+) channel Kir1.1) (Potassium channel, inwardly rectifying subfamily J member 1)
Gene Names:
KCNJ1 ROMK1
Gene Names Primary:
KCNJ1
Organism:
Homo sapiens (Human)

Structure

Length:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane
Intramembrane:
INTRAMEM 128 139 Helical; Pore-forming; Name=H5.

Function

Function:
In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
Enzyme Regulation:
ENZYME REGULATION: Inhibited by WNK3.
Cross Reference Drug Bank:
DB00217 DB00222 DB01016 DB01382 DB00350 DB00839 DB01124 DB01392
Gene Ontology Go:
plasma membrane
voltage-gated potassium channel complex
ATP binding
ATP-activated inward rectifier potassium channel activity
inward rectifier potassium channel activity
peptide binding
phosphatidylinositol-4,5-bisphosphate binding
potassium ion binding
cellular response to magnesium ion
excretion
negative regulation of apoptotic process
potassium ion import
potassium ion transport
response to potassium ion
synaptic transmission
Gene Ontology Biological Process:
cellular response to magnesium ion
excretion
negative regulation of apoptotic process
potassium ion import
potassium ion transport
response to potassium ion
synaptic transmission
Gene Ontology Molecular Function:
ATP-activated inward rectifier potassium channel activity
ATP binding
inward rectifier potassium channel activity
peptide binding
phosphatidylinositol-4,5-bisphosphate binding
potassium ion binding
Gene Ontology Cellular Component:
plasma membrane
voltage-gated potassium channel complex
Keywords:
ATP-binding
Alternative splicing
Bartter syndrome
Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Ion channel
Ion transport
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Potassium
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
7929082 8190102 9099852 15489334 7635463 10889209 14623317 12684516 16357011 8841184 9002665 9727001 16959974