Names & Taxonomy
- Uniprot ID:
- P47898
- Entry Name:
- 5HT5A_HUMAN
- Status:
- reviewed
- Protein Names:
- 5-hydroxytryptamine receptor 5A (5-HT-5) (5-HT-5A) (5-HT5A) (Serotonin receptor 5A)
- Gene Names:
- HTR5A
- Gene Names Primary:
- HTR5A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 357
- Sequence:
- MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.
- Cross Reference Drug Bank:
- DB06216 DB00408 DB00334
- Gene Ontology Go:
- dendrite
Golgi apparatus
integral component of plasma membrane
perikaryon
plasma membrane
rough endoplasmic reticulum
G-protein coupled serotonin receptor activity
cAMP-mediated signaling
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
hippocampus development
response to estradiol - Gene Ontology Biological Process:
- cAMP-mediated signaling
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
hippocampus development
response to estradiol - Gene Ontology Molecular Function:
- G-protein coupled serotonin receptor activity
- Gene Ontology Cellular Component:
- dendrite
Golgi apparatus
integral component of plasma membrane
perikaryon
plasma membrane
rough endoplasmic reticulum - Keywords:
- Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix