Names & Taxonomy
- Uniprot ID:
- P46926
- Entry Name:
- GNPI1_HUMAN
- Status:
- reviewed
- Protein Names:
- Glucosamine-6-phosphate isomerase 1 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 1) (GNPDA 1) (GlcN6P deaminase 1) (Oscillin)
- Gene Names:
- GNPDA1 GNPI HLN KIAA0060
- Gene Names Primary:
- GNPDA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 289
- Sequence:
- MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKSQSSKKPYSD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).
- Catalytic Activity:
- Alpha-D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3).
- Active Site:
- ACT_SITE 72 72 Proton acceptor; for enolization step.
- Gene Ontology Go:
- cytoplasm
extracellular exosome
glucosamine-6-phosphate deaminase activity
hydrolase activity
carbohydrate metabolic process
generation of precursor metabolites and energy
glucosamine catabolic process
N-acetylglucosamine metabolic process
single fertilization - Gene Ontology Biological Process:
- carbohydrate metabolic process
generation of precursor metabolites and energy
glucosamine catabolic process
N-acetylglucosamine metabolic process
single fertilization - Gene Ontology Molecular Function:
- glucosamine-6-phosphate deaminase activity
hydrolase activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Carbohydrate metabolism
Complete proteome
Cytoplasm
Hydrolase
Phosphoprotein
Reference proteome - Interacts With:
- P43364-2; Q9NRG1