Names & Taxonomy
- Uniprot ID:
- P46597
- Entry Name:
- ASMT_HUMAN
- Status:
- reviewed
- Protein Names:
- Acetylserotonin O-methyltransferase (EC 2.1.1.4) (Hydroxyindole O-methyltransferase) (HIOMT)
- Gene Names:
- ASMT
- Gene Names Primary:
- ASMT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 345
- Sequence:
- MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPLDVAAVAAGVRASAHGTELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPTSQCSMLKYMGRTSYRCWGHLADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQALQEVWSVNGRSVLTAFDLSVFPLMCDLGGGAGALAKECMSLYPGCKITVFDIPEVVWTAKQHFSFQEEEQIDFQEGDFFKDPLPEADLYILARVLHDWADGKCSHLLERIYHTCKPGGGILVIESLLDEDRRGPLLTQLYSLNMLVQTEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK
- Proteomes:
- UP000005640
Function
- Function:
- Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
- Pathway:
- Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
- Catalytic Activity:
- S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.
- Active Site:
- ACT_SITE 255 255 Proton donor/acceptor.
- Cross Reference Drug Bank:
- DB01065
- Gene Ontology Go:
- cytosol
acetylserotonin O-methyltransferase activity
identical protein binding
O-methyltransferase activity
protein homodimerization activity
cellular nitrogen compound metabolic process
indolalkylamine biosynthetic process
melatonin biosynthetic process
small molecule metabolic process
translation - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
indolalkylamine biosynthetic process
melatonin biosynthetic process
small molecule metabolic process
translation - Gene Ontology Molecular Function:
- acetylserotonin O-methyltransferase activity
identical protein binding
O-methyltransferase activity
protein homodimerization activity - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Melatonin biosynthesis
Methyltransferase
Polymorphism
Reference proteome
S-adenosyl-L-methionine
Transferase - Interacts With:
- Itself