Names & Taxonomy
- Uniprot ID:
- P46089
- Entry Name:
- GPR3_HUMAN
- Status:
- reviewed
- Protein Names:
- G-protein coupled receptor 3 (ACCA orphan receptor)
- Gene Names:
- GPR3 ACCA
- Gene Names Primary:
- GPR3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 330
- Sequence:
- MMWGAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSPSDV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).
- Gene Ontology Go:
- integral component of plasma membrane
G-protein coupled receptor activity
adenylate cyclase-activating G-protein coupled receptor signaling pathway
regulation of meiotic nuclear division - Gene Ontology Biological Process:
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
regulation of meiotic nuclear division - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
- Gene Ontology Cellular Component:
- integral component of plasma membrane
- Keywords:
- Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P05067-4